Transcription meets metabolism in neurodegeneration

Christopher A. Ross, Leslie Michels Thompson

Research output: Contribution to journalShort survey

Abstract

A molecular basis for the metabolic abnormalities observed in Huntington disease is emerging. Transcription of a key mitochondrial regulator, PGC-1α, is dysregulated by mutant huntingtin, leading to oxidative stress and excitotoxicity. The findings dovetail with previous work implicating aberrant transcription in Huntington disease, and have implications for related conditions such as Parkinson disease.

Original languageEnglish (US)
Pages (from-to)1239-1241
Number of pages3
JournalNature medicine
Volume12
Issue number11
DOIs
StatePublished - Nov 1 2006

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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