Transcription factor sox9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium

Tomohiro Masuda; Karl Wahlin; Jun Wan; Jianfei Hu; Julien Maruotti; Xue Yang; Jared Iacovelli; Natalie Wolkow; Ralf Kist; Joshua L. Dunaief; Jiang Qian; Donald J. Zack; Noriko Esumi

doi:10.1074/jbc.M114.556738

Transcription factor sox9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium

Tomohiro Masuda, Karl Wahlin, Jun Wan, Jianfei Hu, Julien Maruotti, Xue Yang, Jared Iacovelli, Natalie Wolkow, Ralf Kist, Joshua L. Dunaief, Jiang Qian, Donald J. Zack, Noriko Esumi

School of Medicine

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Background: The visual cycle is an enzymatic cascade that regenerates the visual chromophore. Results: Visual cycle gene expression is regulated by SOX9 in combination with OTX2 or LHX2 and can be modulated by common microRNAs. Conclusion: A core transcriptional network involving SOX9 regulates visual cycle genes. Significance: Understanding visual cycle gene regulation may have implications for treating retinal degenerative diseases.

Original language	English (US)
Pages (from-to)	12908-12921
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	289
Issue number	18
DOIs	https://doi.org/10.1074/jbc.M114.556738
State	Published - 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M114.556738

Cite this

Masuda, T., Wahlin, K., Wan, J., Hu, J., Maruotti, J., Yang, X., Iacovelli, J., Wolkow, N., Kist, R., Dunaief, J. L., Qian, J., Zack, D. J., & Esumi, N. (2014). Transcription factor sox9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium. Journal of Biological Chemistry, 289(18), 12908-12921. https://doi.org/10.1074/jbc.M114.556738

Masuda, T, Wahlin, K, Wan, J, Hu, J, Maruotti, J, Yang, X, Iacovelli, J, Wolkow, N, Kist, R, Dunaief, JL, Qian, J , Zack, DJ & Esumi, N 2014, 'Transcription factor sox9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium', Journal of Biological Chemistry, vol. 289, no. 18, pp. 12908-12921. https://doi.org/10.1074/jbc.M114.556738

@article{693bc4c6c66e423b85d4c1890d28ed00,

title = "Transcription factor sox9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium",

abstract = "Background: The visual cycle is an enzymatic cascade that regenerates the visual chromophore. Results: Visual cycle gene expression is regulated by SOX9 in combination with OTX2 or LHX2 and can be modulated by common microRNAs. Conclusion: A core transcriptional network involving SOX9 regulates visual cycle genes. Significance: Understanding visual cycle gene regulation may have implications for treating retinal degenerative diseases.",

author = "Tomohiro Masuda and Karl Wahlin and Jun Wan and Jianfei Hu and Julien Maruotti and Xue Yang and Jared Iacovelli and Natalie Wolkow and Ralf Kist and Dunaief, {Joshua L.} and Jiang Qian and Zack, {Donald J.} and Noriko Esumi",

year = "2014",

doi = "10.1074/jbc.M114.556738",

language = "English (US)",

volume = "289",

pages = "12908--12921",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "18",

}

TY - JOUR

T1 - Transcription factor sox9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium

AU - Masuda, Tomohiro

AU - Wahlin, Karl

AU - Wan, Jun

AU - Hu, Jianfei

AU - Maruotti, Julien

AU - Yang, Xue

AU - Iacovelli, Jared

AU - Wolkow, Natalie

AU - Kist, Ralf

AU - Dunaief, Joshua L.

AU - Qian, Jiang

AU - Zack, Donald J.

AU - Esumi, Noriko

PY - 2014

Y1 - 2014

N2 - Background: The visual cycle is an enzymatic cascade that regenerates the visual chromophore. Results: Visual cycle gene expression is regulated by SOX9 in combination with OTX2 or LHX2 and can be modulated by common microRNAs. Conclusion: A core transcriptional network involving SOX9 regulates visual cycle genes. Significance: Understanding visual cycle gene regulation may have implications for treating retinal degenerative diseases.

AB - Background: The visual cycle is an enzymatic cascade that regenerates the visual chromophore. Results: Visual cycle gene expression is regulated by SOX9 in combination with OTX2 or LHX2 and can be modulated by common microRNAs. Conclusion: A core transcriptional network involving SOX9 regulates visual cycle genes. Significance: Understanding visual cycle gene regulation may have implications for treating retinal degenerative diseases.

UR - http://www.scopus.com/inward/record.url?scp=84899707851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899707851&partnerID=8YFLogxK

U2 - 10.1074/jbc.M114.556738

DO - 10.1074/jbc.M114.556738

M3 - Article

C2 - 24634209

AN - SCOPUS:84899707851

SN - 0021-9258

VL - 289

SP - 12908

EP - 12921

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 18

ER -

Transcription factor sox9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this