Transcription factor sox9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium

Tomohiro Masuda, Karl Wahlin, Jun Wan, Jianfei Hu, Julien Maruotti, Xue Yang, Jared Iacovelli, Natalie Wolkow, Ralf Kist, Joshua L. Dunaief, Jiang Qian, Donald J. Zack, Noriko Esumi

Research output: Contribution to journalArticle

Abstract

Background: The visual cycle is an enzymatic cascade that regenerates the visual chromophore. Results: Visual cycle gene expression is regulated by SOX9 in combination with OTX2 or LHX2 and can be modulated by common microRNAs. Conclusion: A core transcriptional network involving SOX9 regulates visual cycle genes. Significance: Understanding visual cycle gene regulation may have implications for treating retinal degenerative diseases.

Original languageEnglish (US)
Pages (from-to)12908-12921
Number of pages14
JournalJournal of Biological Chemistry
Volume289
Issue number18
DOIs
StatePublished - Jan 1 2014

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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