TY - JOUR
T1 - Transcription factor mechanisms guiding motor neuron differentiation and diversification
AU - Cave, Clinton
AU - Sockanathan, Shanthini
N1 - Funding Information:
Research in the laboratory was supported by grants from the Muscular Dystrophy Association and the National Institutes of Health (NINDS, RO1NS046336 ).
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/12
Y1 - 2018/12
N2 - The embryonic generation of motor neurons is a complex process involving progenitor patterning, fate specification, differentiation, and maturation. Throughout this progression, the differential expression of transcription factors has served as our road map for the eventual cell fate of nascent motor neurons. Recent findings from in vivo and in vitro models of motor neuron development have expanded our understanding of how transcription factors govern motor neuron identity and their individual regulatory mechanisms. With the advent of next generation sequencing approaches, researchers now have unprecedented access to the gene regulatory dynamics involved in motor neuron development and are uncovering new connections linking neurodevelopment and neurodegenerative disease.
AB - The embryonic generation of motor neurons is a complex process involving progenitor patterning, fate specification, differentiation, and maturation. Throughout this progression, the differential expression of transcription factors has served as our road map for the eventual cell fate of nascent motor neurons. Recent findings from in vivo and in vitro models of motor neuron development have expanded our understanding of how transcription factors govern motor neuron identity and their individual regulatory mechanisms. With the advent of next generation sequencing approaches, researchers now have unprecedented access to the gene regulatory dynamics involved in motor neuron development and are uncovering new connections linking neurodevelopment and neurodegenerative disease.
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U2 - 10.1016/j.conb.2018.04.012
DO - 10.1016/j.conb.2018.04.012
M3 - Review article
C2 - 29694927
AN - SCOPUS:85046023338
SN - 0959-4388
VL - 53
SP - 1
EP - 7
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -