Transcription factor levels in medullary thyroid carcinoma cells differentiated by Harvey ras oncogene: C-jun in increased

Barry D. Nelkin, Michael Borges, Mack Mabry, Stephen B. Baylin

Research output: Contribution to journalArticlepeer-review

Abstract

In the TT cell line of human medullary thyroid carcinoma, the viral Harvey ras (v-rasH) oncogene induces differentiation, marked by morphological changes, diminution of growth, and increased expression of the calcitonin gene. Here, we show that the transcriptional factor c-jun is increased during v-rasH induced differentiation of TT cells both at the mRNA and functional protein levels. In contrast, nuclear proteins with binding activities related to AP2, AP3, NF1 CTF, and Sp1 were unchanged in v-rasH differentiated TT cells.

Original languageEnglish (US)
Pages (from-to)140-146
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume170
Issue number1
DOIs
StatePublished - Jul 16 1990

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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