TY - JOUR
T1 - Transcription factor levels in medullary thyroid carcinoma cells differentiated by Harvey ras oncogene
T2 - C-jun in increased
AU - Nelkin, Barry D.
AU - Borges, Michael
AU - Mabry, Mack
AU - Baylin, Stephen B.
PY - 1990/7/16
Y1 - 1990/7/16
N2 - In the TT cell line of human medullary thyroid carcinoma, the viral Harvey ras (v-rasH) oncogene induces differentiation, marked by morphological changes, diminution of growth, and increased expression of the calcitonin gene. Here, we show that the transcriptional factor c-jun is increased during v-rasH induced differentiation of TT cells both at the mRNA and functional protein levels. In contrast, nuclear proteins with binding activities related to AP2, AP3, NF1 CTF, and Sp1 were unchanged in v-rasH differentiated TT cells.
AB - In the TT cell line of human medullary thyroid carcinoma, the viral Harvey ras (v-rasH) oncogene induces differentiation, marked by morphological changes, diminution of growth, and increased expression of the calcitonin gene. Here, we show that the transcriptional factor c-jun is increased during v-rasH induced differentiation of TT cells both at the mRNA and functional protein levels. In contrast, nuclear proteins with binding activities related to AP2, AP3, NF1 CTF, and Sp1 were unchanged in v-rasH differentiated TT cells.
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U2 - 10.1016/0006-291X(90)91251-M
DO - 10.1016/0006-291X(90)91251-M
M3 - Article
C2 - 2115330
AN - SCOPUS:0025078623
SN - 0006-291X
VL - 170
SP - 140
EP - 146
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -