Transcription Factor Hand-offs “Enhance” Motor Neuron Differentiation

Clinton Cave, Shanthini Sockanathan

Research output: Contribution to journalShort surveypeer-review

Abstract

Rhee et al. (2016) in this issue of Neuron and Velasco et al. (2016) in Cell Stem Cell find that the activity of transcription factors binding sequentially to a series of transient early and late enhancers directs gene expression that is essential for motor neuron differentiation and function.

Original languageEnglish (US)
Pages (from-to)1149-1151
Number of pages3
JournalNeuron
Volume92
Issue number6
DOIs
StatePublished - Dec 21 2016

Keywords

  • differentiation
  • directed programming
  • enhancer
  • motor neuron
  • temporal occupancy
  • transcription factor

ASJC Scopus subject areas

  • Neuroscience(all)

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