Transcription Factor Hand-offs “Enhance” Motor Neuron Differentiation

Clinton Cave, Shanthini Sockanathan

Research output: Contribution to journalShort survey

Abstract

Rhee et al. (2016) in this issue of Neuron and Velasco et al. (2016) in Cell Stem Cell find that the activity of transcription factors binding sequentially to a series of transient early and late enhancers directs gene expression that is essential for motor neuron differentiation and function.

Original languageEnglish (US)
Pages (from-to)1149-1151
Number of pages3
JournalNeuron
Volume92
Issue number6
DOIs
StatePublished - Dec 21 2016

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Keywords

  • differentiation
  • directed programming
  • enhancer
  • motor neuron
  • temporal occupancy
  • transcription factor

ASJC Scopus subject areas

  • Neuroscience(all)

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