TY - JOUR
T1 - Transcription factor GATA-1 in megakaryocyte development.
AU - Orkin, S. H.
AU - Shivdasani, R. A.
AU - Fujiwara, Y.
AU - McDevitt, M. A.
PY - 1998
Y1 - 1998
N2 - The transcription factor GATA-1 is specifically expressed in hematopoietic lineages. Prior gene knockout experiments established an essential role for GATA-1 in red blood cell production, but could not provide direct evidence with respect to a requirement in megakaryopoiesis. We summarize here recent lineage-selective gene targeting in mice that establishes critical functions for GATA-1 in controlling megakaryocyte growth and maturation, and platelet production. GATA-1 megakaryocytes are delayed in their cellular maturation, exhibit marked hyperproliferation and generate fewer than normal, yet enlarged, platelets in vivo. Thus GATA-1 is a central regulator in both the erythroid and megakaryocytic lineages.
AB - The transcription factor GATA-1 is specifically expressed in hematopoietic lineages. Prior gene knockout experiments established an essential role for GATA-1 in red blood cell production, but could not provide direct evidence with respect to a requirement in megakaryopoiesis. We summarize here recent lineage-selective gene targeting in mice that establishes critical functions for GATA-1 in controlling megakaryocyte growth and maturation, and platelet production. GATA-1 megakaryocytes are delayed in their cellular maturation, exhibit marked hyperproliferation and generate fewer than normal, yet enlarged, platelets in vivo. Thus GATA-1 is a central regulator in both the erythroid and megakaryocytic lineages.
UR - http://www.scopus.com/inward/record.url?scp=0032227812&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032227812&partnerID=8YFLogxK
U2 - 10.1002/stem.5530160710
DO - 10.1002/stem.5530160710
M3 - Review article
C2 - 11012179
AN - SCOPUS:0032227812
SN - 1066-5099
VL - 16 Suppl 2
SP - 79
EP - 83
JO - Stem cells (Dayton, Ohio)
JF - Stem cells (Dayton, Ohio)
ER -