Abstract
The transcription factor GATA-1 is specifically expressed in hematopoietic lineages. Prior gene knockout experiments established an essential role for GATA-1 in red blood cell production, but could not provide direct evidence with respect to a requirement in megakaryopoiesis. We summarize here recent lineage-selective gene targeting in mice that establishes critical functions for GATA-1 in controlling megakaryocyte growth and maturation, and platelet production. GATA-1 megakaryocytes are delayed in their cellular maturation, exhibit marked hyperproliferation and generate fewer than normal, yet enlarged, platelets in vivo. Thus GATA-1 is a central regulator in both the erythroid and megakaryocytic lineages.
Original language | English (US) |
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Pages (from-to) | 79-83 |
Number of pages | 5 |
Journal | Stem cells (Dayton, Ohio) |
Volume | 16 Suppl 2 |
DOIs | |
State | Published - 1998 |
ASJC Scopus subject areas
- Molecular Medicine
- Developmental Biology
- Cell Biology