Transcription factor GATA-1 in megakaryocyte development.

S. H. Orkin, R. A. Shivdasani, Y. Fujiwara, M. A. McDevitt

Research output: Contribution to journalReview articlepeer-review

Abstract

The transcription factor GATA-1 is specifically expressed in hematopoietic lineages. Prior gene knockout experiments established an essential role for GATA-1 in red blood cell production, but could not provide direct evidence with respect to a requirement in megakaryopoiesis. We summarize here recent lineage-selective gene targeting in mice that establishes critical functions for GATA-1 in controlling megakaryocyte growth and maturation, and platelet production. GATA-1 megakaryocytes are delayed in their cellular maturation, exhibit marked hyperproliferation and generate fewer than normal, yet enlarged, platelets in vivo. Thus GATA-1 is a central regulator in both the erythroid and megakaryocytic lineages.

Original languageEnglish (US)
Pages (from-to)79-83
Number of pages5
JournalStem cells (Dayton, Ohio)
Volume16 Suppl 2
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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