Transcranial doppler to predict neurologic outcome after mild to moderate traumatic brain injury

Pierre Bouzat, Luc Almeras, Pauline Manhes, Laurence Sanders, Albrice Levrat, Jean Stephane David, Raphael Cinotti, Russel Chabanne, Aurélie Gloaguen, Xavier Bobbia, Sophie Thoret, Lydia Oujamaa, Jean Luc Bosson, Jean François Payen

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Background: To assess the performance of transcranial Doppler (TCD) in predicting neurologic worsening after mild to moderate traumatic brain injury. Methods: The authors conducted a prospective observational study across 17 sites. TCD was performed upon admission in 356 patients (Glasgow Coma Score [GCS], 9 to 15) with mild lesions on cerebral computed tomography scan. Normal TCD was defined as a pulsatility index of less than 1.25 and diastolic blood flow velocity higher than 25 cm/s in the two middle cerebral arteries. The primary endpoint was secondary neurologic deterioration on day 7. Results: Twenty patients (6%) developed secondary neurologic deterioration within the first posttraumatic week. TCD thresholds had 80% sensitivity (95% CI, 56 to 94%) and 79% specificity (95% CI, 74 to 83%) to predict neurologic worsening. The negative predictive values and positive predictive values of TCD were 98% (95% CI, 96 to 100%) and 18% (95% CI, 11to 28%), respectively. In patients with minor traumatic brain injury (GCS, 14 to 15), the sensitivity and specificity of TCD were 91% (95% CI, 59 to 100%) and 80% (95% CI, 75 to 85%), respectively. The area under the receiver operating characteristic curve of a multivariate predictive model including age and GCS was significantly improved with the adjunction of TCD. Patients with abnormal TCD on admission (n = 86 patients) showed a more altered score for the disability rating scale on day 28 compared to those with normal TCD (n = 257 patients). Conclusions: TCD measurements upon admission may provide additional information about neurologic outcome after mild to moderate traumatic brain injury. This technique could be useful for in-hospital triage in this context.

Original languageEnglish (US)
Pages (from-to)346-354
Number of pages9
Issue number2
StatePublished - Aug 1 2016

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Transcranial doppler to predict neurologic outcome after mild to moderate traumatic brain injury'. Together they form a unique fingerprint.

Cite this