@article{5730a4304cbd4d4793dbbd0a9163e04c,
title = "Transcontinental dispersal of Anopheles gambiae occurred from West African origin via serial founder events",
abstract = "The mosquito Anopheles gambiae s.s. is distributed across most of sub-Saharan Africa and is of major scientific and public health interest for being an African malaria vector. Here we present population genomic analyses of 111 specimens sampled from west to east Africa, including the first whole genome sequences from oceanic islands, the Comoros. Genetic distances between populations of A. gambiae are discordant with geographic distances but are consistent with a stepwise migration scenario in which the species increases its range from west to east Africa through consecutive founder events over the last ~200,000 years. Geological barriers like the Congo River basin and the East African rift seem to play an important role in shaping this process. Moreover, we find a high degree of genetic isolation of populations on the Comoros, confirming the potential of these islands as candidate sites for potential field trials of genetically engineered mosquitoes for malaria control.",
author = "Hanno Schmidt and Yoosook Lee and Collier, {Travis C.} and Hanemaaijer, {Mark J.} and Kirstein, {Oscar D.} and Ahmed Ouledi and Mbanga Muleba and Norris, {Douglas E.} and Montgomery Slatkin and Cornel, {Anthony J.} and Lanzaro, {Gregory C.}",
note = "Funding Information: We thank Kija N{\textquoteright}ghabi (Ifakara Health Institute) for providing samples from Tanzania. We thank Lutz Froenicke and his team at the UC Davis DNA Technologies Core for carrying out genome sequencing. We thank Hugh Dingle (UC Davis) for his advice on potential migration sources around the Comoros. We thank Youki Yamasaki and Catelyn Neiman for their outstanding workmanship carrying out DNA extraction and genomic DNA library preparations. We also thank Ann-Marie Waldvogel (Senckenberg BiK-F) for very helpful discussions on cross-coalescence analyses. Collections in Zambia were supported by the NIH-funded Southern and Central Africa International Centers of Excellence for Malaria Research (2U19AI089680). This work was supported by the University of California Davis Bridge Funding, UC Davis Signature Research in Genomics Program, National Institutes of Health grant R56 AI130277, and the University of California Irvine Malaria Initiative.",
year = "2019",
month = dec,
day = "1",
doi = "10.1038/s42003-019-0717-7",
language = "English (US)",
volume = "2",
journal = "Communications Biology",
issn = "2399-3642",
publisher = "Springer Nature",
number = "1",
}