Transcatheter arterial chemoembolization of liver tumors

Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency

Jean Francois H Geschwind, Douglas E. Ramsey, Berry Cleffken, B. C H Van der Wal, Hicham Kobeiter, Krishna Juluru, George G. Hartnell, Michael A. Choti

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to determine whether transcatheter arterial chemoembolization (TACE) protocol affects the total volume of chemotherapy injected into the liver as well as subsequent arterial patency. A total of 160 patients with primary or secondary liver cancer were treated with 3 different chemoembolization protocols at a single institution. Data were analyzed retrospectively. Group 1 (n = 36) consisted of slurry of chemotherapy, oil and polyvinyl alcohol particles (PVA), group 2 (n = 91), chemotherapy and oil followed by PVA, and group 3 (n = 33), chemotherapy and oil followed by Gelfoam pledgets. The total volume of chemotherapy injected into the liver was recorded. Arterial patency was determined during subsequent chemoembolizations. The mean percentage of total intended chemotherapy dose administered was 54.6% for group 1, 75.3% for group 2, and 80.6% for group 3. Arterial patency at follow-up angiography was 56% for group 1, 74% for group 2, and 81% for group 3. The slurry protocol (group 1) significantly reduced arterial patency and injectable volume of chemotherapy during TACE.

Original languageEnglish (US)
Pages (from-to)111-117
Number of pages7
JournalCardioVascular and Interventional Radiology
Volume26
Issue number2
DOIs
StatePublished - Mar 2003

Fingerprint

Drug Therapy
Injections
Liver
Neoplasms
Polyvinyl Alcohol
Oils
Absorbable Gelatin Sponge
Liver Neoplasms
Angiography

Keywords

  • Angiography
  • Arteries
  • Blood supply
  • Chemotherapeutic embolization
  • Embolic material
  • Liver neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Transcatheter arterial chemoembolization of liver tumors : Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency. / Geschwind, Jean Francois H; Ramsey, Douglas E.; Cleffken, Berry; Van der Wal, B. C H; Kobeiter, Hicham; Juluru, Krishna; Hartnell, George G.; Choti, Michael A.

In: CardioVascular and Interventional Radiology, Vol. 26, No. 2, 03.2003, p. 111-117.

Research output: Contribution to journalArticle

Geschwind, Jean Francois H ; Ramsey, Douglas E. ; Cleffken, Berry ; Van der Wal, B. C H ; Kobeiter, Hicham ; Juluru, Krishna ; Hartnell, George G. ; Choti, Michael A. / Transcatheter arterial chemoembolization of liver tumors : Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency. In: CardioVascular and Interventional Radiology. 2003 ; Vol. 26, No. 2. pp. 111-117.
@article{37c3d5fc981d4bb987832d24c5f50ac8,
title = "Transcatheter arterial chemoembolization of liver tumors: Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency",
abstract = "The purpose of this study was to determine whether transcatheter arterial chemoembolization (TACE) protocol affects the total volume of chemotherapy injected into the liver as well as subsequent arterial patency. A total of 160 patients with primary or secondary liver cancer were treated with 3 different chemoembolization protocols at a single institution. Data were analyzed retrospectively. Group 1 (n = 36) consisted of slurry of chemotherapy, oil and polyvinyl alcohol particles (PVA), group 2 (n = 91), chemotherapy and oil followed by PVA, and group 3 (n = 33), chemotherapy and oil followed by Gelfoam pledgets. The total volume of chemotherapy injected into the liver was recorded. Arterial patency was determined during subsequent chemoembolizations. The mean percentage of total intended chemotherapy dose administered was 54.6{\%} for group 1, 75.3{\%} for group 2, and 80.6{\%} for group 3. Arterial patency at follow-up angiography was 56{\%} for group 1, 74{\%} for group 2, and 81{\%} for group 3. The slurry protocol (group 1) significantly reduced arterial patency and injectable volume of chemotherapy during TACE.",
keywords = "Angiography, Arteries, Blood supply, Chemotherapeutic embolization, Embolic material, Liver neoplasms",
author = "Geschwind, {Jean Francois H} and Ramsey, {Douglas E.} and Berry Cleffken and {Van der Wal}, {B. C H} and Hicham Kobeiter and Krishna Juluru and Hartnell, {George G.} and Choti, {Michael A.}",
year = "2003",
month = "3",
doi = "10.1007/s00270-002-2524-6",
language = "English (US)",
volume = "26",
pages = "111--117",
journal = "CardioVascular and Interventional Radiology",
issn = "7415-5101",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Transcatheter arterial chemoembolization of liver tumors

T2 - Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency

AU - Geschwind, Jean Francois H

AU - Ramsey, Douglas E.

AU - Cleffken, Berry

AU - Van der Wal, B. C H

AU - Kobeiter, Hicham

AU - Juluru, Krishna

AU - Hartnell, George G.

AU - Choti, Michael A.

PY - 2003/3

Y1 - 2003/3

N2 - The purpose of this study was to determine whether transcatheter arterial chemoembolization (TACE) protocol affects the total volume of chemotherapy injected into the liver as well as subsequent arterial patency. A total of 160 patients with primary or secondary liver cancer were treated with 3 different chemoembolization protocols at a single institution. Data were analyzed retrospectively. Group 1 (n = 36) consisted of slurry of chemotherapy, oil and polyvinyl alcohol particles (PVA), group 2 (n = 91), chemotherapy and oil followed by PVA, and group 3 (n = 33), chemotherapy and oil followed by Gelfoam pledgets. The total volume of chemotherapy injected into the liver was recorded. Arterial patency was determined during subsequent chemoembolizations. The mean percentage of total intended chemotherapy dose administered was 54.6% for group 1, 75.3% for group 2, and 80.6% for group 3. Arterial patency at follow-up angiography was 56% for group 1, 74% for group 2, and 81% for group 3. The slurry protocol (group 1) significantly reduced arterial patency and injectable volume of chemotherapy during TACE.

AB - The purpose of this study was to determine whether transcatheter arterial chemoembolization (TACE) protocol affects the total volume of chemotherapy injected into the liver as well as subsequent arterial patency. A total of 160 patients with primary or secondary liver cancer were treated with 3 different chemoembolization protocols at a single institution. Data were analyzed retrospectively. Group 1 (n = 36) consisted of slurry of chemotherapy, oil and polyvinyl alcohol particles (PVA), group 2 (n = 91), chemotherapy and oil followed by PVA, and group 3 (n = 33), chemotherapy and oil followed by Gelfoam pledgets. The total volume of chemotherapy injected into the liver was recorded. Arterial patency was determined during subsequent chemoembolizations. The mean percentage of total intended chemotherapy dose administered was 54.6% for group 1, 75.3% for group 2, and 80.6% for group 3. Arterial patency at follow-up angiography was 56% for group 1, 74% for group 2, and 81% for group 3. The slurry protocol (group 1) significantly reduced arterial patency and injectable volume of chemotherapy during TACE.

KW - Angiography

KW - Arteries

KW - Blood supply

KW - Chemotherapeutic embolization

KW - Embolic material

KW - Liver neoplasms

UR - http://www.scopus.com/inward/record.url?scp=0042267397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042267397&partnerID=8YFLogxK

U2 - 10.1007/s00270-002-2524-6

DO - 10.1007/s00270-002-2524-6

M3 - Article

VL - 26

SP - 111

EP - 117

JO - CardioVascular and Interventional Radiology

JF - CardioVascular and Interventional Radiology

SN - 7415-5101

IS - 2

ER -