Transcatheter arterial chemoembolization of liver tumors: Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency

Jean Francois H. Geschwind, Douglas E. Ramsey, Berry Cleffken, B. C.H. Van der Wal, Hicham Kobeiter, Krishna Juluru, George G. Hartnell, Michael A. Choti

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to determine whether transcatheter arterial chemoembolization (TACE) protocol affects the total volume of chemotherapy injected into the liver as well as subsequent arterial patency. A total of 160 patients with primary or secondary liver cancer were treated with 3 different chemoembolization protocols at a single institution. Data were analyzed retrospectively. Group 1 (n = 36) consisted of slurry of chemotherapy, oil and polyvinyl alcohol particles (PVA), group 2 (n = 91), chemotherapy and oil followed by PVA, and group 3 (n = 33), chemotherapy and oil followed by Gelfoam pledgets. The total volume of chemotherapy injected into the liver was recorded. Arterial patency was determined during subsequent chemoembolizations. The mean percentage of total intended chemotherapy dose administered was 54.6% for group 1, 75.3% for group 2, and 80.6% for group 3. Arterial patency at follow-up angiography was 56% for group 1, 74% for group 2, and 81% for group 3. The slurry protocol (group 1) significantly reduced arterial patency and injectable volume of chemotherapy during TACE.

Original languageEnglish (US)
Pages (from-to)111-117
Number of pages7
JournalCardiovascular and interventional radiology
Volume26
Issue number2
DOIs
StatePublished - Mar 1 2003

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Keywords

  • Angiography
  • Arteries
  • Blood supply
  • Chemotherapeutic embolization
  • Embolic material
  • Liver neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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