Transbronchial lung biopsy in sarcoidosis. An approach to determine the optimal number of biopsies

M. J. Gilman, K. P. Wang

Research output: Contribution to journalArticlepeer-review

Abstract

In order to determine if the diagnosis yield of the transbronchial lung biopsy in sarcoidosis is dependent upon the number of biopsies, a study was designed to examine individual specimens from 6 biopsies in patients with Stage II sarcoidosis. It was found that the probability of obtaining a positive specimen per biopsy was 46%, and this percentage remained constant for each biopsy. The diagnostic yield followed a logarithmic curve, gradually increasing from 1 through 4 biopsies until about 90% of true positive diagnoses were obtained, then approaching a plateau with successive biopsies. We therefore recommend that 4 transbronchial lung biopsies are sufficient to diagnose stage II sarcoidosis in the majority of patients with diffuse lung disease.

Original languageEnglish (US)
Pages (from-to)721-724
Number of pages4
JournalAmerican Review of Respiratory Disease
Volume122
Issue number5 I
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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