Transapical aortic valve replacement under real-time magnetic resonance imaging guidance: Experimental results with balloon-expandable and self-expanding stents

Keith A. Horvath, Dumitru Mazilu, Ozgur Kocaturk, Ming Li

Research output: Contribution to journalArticle

Abstract

Objective: Aortic valves have been implanted on self-expanding (SE) and balloon-expandable (BE) stents minimally invasively. We have demonstrated the advantages of transapical aortic valve implantation (tAVI) under real-time magnetic resonance imaging (rtMRI) guidance. Whether there are different advantages to SE or BE stents is unknown. We report rtMRI-guided tAVI in a porcine model using both SE and BE stents, and compare the differences between the stents. Methods: A total of 22 Yucatan pigs (45-57. kg) underwent tAVI. Commercially available stentless bioprostheses (21-25. mm) were mounted on either BE platinum-iridium stents or SE-nitinol stents. rtMRI guidance was employed as the intraoperative imaging. Markers on both types of stents were used to enhance visualization in rtMRI. Pigs were allowed to survive and had follow-up MRI scans and echocardiography at 1, 3, and 6 months postoperatively. Results: rtMRI provided excellent visualization of the aortic valve implantation mounted on both stent types. The implantation times were shorter with the SE stents (60 ± 14. s) than with the BE stents (74 ± 18. s), (p= 0.027). The total procedure time was 31 and 37. min, respectively (p= 0.12). It was considerably easier to manipulate the SE stent during deployment, without hemodynamic compromise. This was not always the case with the BE stent, and its placement occasionally resulted in coronary obstruction and death. Long-term results demonstrated stability of the implants with preservation of myocardial perfusion and function over time for both stents. Conclusions: SE stents were easier to position and deploy, thus leading to fewer complications during tAVI. Future optimization of SE stent design should improve clinical results.

Original languageEnglish (US)
Pages (from-to)822-828
Number of pages7
JournalEuropean Journal of Cardio-thoracic Surgery
Volume39
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • Balloon-expandable stent
  • RtMRI guidance
  • Self-expanding stent
  • Transcatheter aortic valve implantation

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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