TY - JOUR
T1 - Trans-synaptic regulation of gene expression
AU - Ginty, David D.
AU - Bading, Hilmar
AU - Greenberg, Michael E.
PY - 1992
Y1 - 1992
N2 - Neurotransmitters regulate gene expression through second messenger cascades that transmit the signal from the plasma membrane to the nucleus of the postsynaptic cell. Ca2+ and cAMP are two of the second messengers that regulate gene expression in response to neurotransmitters. The Ca2+ and cAMP signals induce expression of a class of genes, termed immediate early genes, within minutes of neurotransmitter receptor activation. Many of these genes encode transcription factors that regulate the expression of late response genes. The results of recent experiments have elucidated mechanisms by which neurotransmitter-induced Ca2+ and CAMP signals regulate immediate early gene expression.
AB - Neurotransmitters regulate gene expression through second messenger cascades that transmit the signal from the plasma membrane to the nucleus of the postsynaptic cell. Ca2+ and cAMP are two of the second messengers that regulate gene expression in response to neurotransmitters. The Ca2+ and cAMP signals induce expression of a class of genes, termed immediate early genes, within minutes of neurotransmitter receptor activation. Many of these genes encode transcription factors that regulate the expression of late response genes. The results of recent experiments have elucidated mechanisms by which neurotransmitter-induced Ca2+ and CAMP signals regulate immediate early gene expression.
UR - http://www.scopus.com/inward/record.url?scp=0026873639&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026873639&partnerID=8YFLogxK
U2 - 10.1016/0959-4388(92)90121-Z
DO - 10.1016/0959-4388(92)90121-Z
M3 - Article
C2 - 1322751
AN - SCOPUS:0026873639
SN - 0959-4388
VL - 2
SP - 312
EP - 316
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 3
ER -