Tranexamic acid use in pelvic and/or acetabular fracture surgery: A systematic review and meta-analysis

Henry T. Shu; Jacob D. Mikula; Andrew T. Yu; Babar Shafiq

doi:10.1016/j.jor.2021.11.018

Tranexamic acid use in pelvic and/or acetabular fracture surgery: A systematic review and meta-analysis

Henry T. Shu, Jacob D. Mikula, Andrew T. Yu, Babar Shafiq

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: The purpose of this study is to determine whether tranexamic acid (TXA) use was associated with lower rates of blood transfusion in patients undergoing pelvic and/or acetabular fracture surgery. Methods: Four studies were included, 3 of which were included in the pooled data analysis for a total of 308 patients. Results: The transfusion rate was significantly lower in the TXA group (44%) compared with the non-TXA group (57%) (P = 0.02). Conclusion: TXA use was associated with a significantly lower transfusion rate in patients who underwent pelvic and/or acetabular fracture surgery. Level of evidence: Level 3. Systematic review of retrospective cohort studies and prospective randomized controlled trials.

Original language	English (US)
Pages (from-to)	112-116
Number of pages	5
Journal	Journal of Orthopaedics
Volume	28
DOIs	https://doi.org/10.1016/j.jor.2021.11.018
State	Published - Nov 1 2021

Keywords

Acetabulum fracture
Antifibrinolysis
Orthopaedic trauma
Pelvic fracture
Tranexamic acid

ASJC Scopus subject areas

Orthopedics and Sports Medicine

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10.1016/j.jor.2021.11.018

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@article{6f7e60b4832d4947ab78a9023394d4a3,

title = "Tranexamic acid use in pelvic and/or acetabular fracture surgery: A systematic review and meta-analysis",

abstract = "Purpose: The purpose of this study is to determine whether tranexamic acid (TXA) use was associated with lower rates of blood transfusion in patients undergoing pelvic and/or acetabular fracture surgery. Methods: Four studies were included, 3 of which were included in the pooled data analysis for a total of 308 patients. Results: The transfusion rate was significantly lower in the TXA group (44%) compared with the non-TXA group (57%) (P = 0.02). Conclusion: TXA use was associated with a significantly lower transfusion rate in patients who underwent pelvic and/or acetabular fracture surgery. Level of evidence: Level 3. Systematic review of retrospective cohort studies and prospective randomized controlled trials.",

keywords = "Acetabulum fracture, Antifibrinolysis, Orthopaedic trauma, Pelvic fracture, Tranexamic acid",

author = "Shu, {Henry T.} and Mikula, {Jacob D.} and Yu, {Andrew T.} and Babar Shafiq",

note = "Funding Information: For their editorial assistance, we thank Jenni Weems, MS, Kerry Kennedy, BA, and Rachel Box, MS, in the Editorial Services group of The Johns Hopkins Department of Orthopaedic Surgery. Publisher Copyright: {\textcopyright} 2021 Professor P K Surendran Memorial Education Foundation",

year = "2021",

month = nov,

day = "1",

doi = "10.1016/j.jor.2021.11.018",

language = "English (US)",

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pages = "112--116",

journal = "Journal of Orthopaedics",

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T1 - Tranexamic acid use in pelvic and/or acetabular fracture surgery

T2 - A systematic review and meta-analysis

AU - Shu, Henry T.

AU - Mikula, Jacob D.

AU - Yu, Andrew T.

AU - Shafiq, Babar

N1 - Funding Information: For their editorial assistance, we thank Jenni Weems, MS, Kerry Kennedy, BA, and Rachel Box, MS, in the Editorial Services group of The Johns Hopkins Department of Orthopaedic Surgery. Publisher Copyright: © 2021 Professor P K Surendran Memorial Education Foundation

PY - 2021/11/1

Y1 - 2021/11/1

N2 - Purpose: The purpose of this study is to determine whether tranexamic acid (TXA) use was associated with lower rates of blood transfusion in patients undergoing pelvic and/or acetabular fracture surgery. Methods: Four studies were included, 3 of which were included in the pooled data analysis for a total of 308 patients. Results: The transfusion rate was significantly lower in the TXA group (44%) compared with the non-TXA group (57%) (P = 0.02). Conclusion: TXA use was associated with a significantly lower transfusion rate in patients who underwent pelvic and/or acetabular fracture surgery. Level of evidence: Level 3. Systematic review of retrospective cohort studies and prospective randomized controlled trials.

AB - Purpose: The purpose of this study is to determine whether tranexamic acid (TXA) use was associated with lower rates of blood transfusion in patients undergoing pelvic and/or acetabular fracture surgery. Methods: Four studies were included, 3 of which were included in the pooled data analysis for a total of 308 patients. Results: The transfusion rate was significantly lower in the TXA group (44%) compared with the non-TXA group (57%) (P = 0.02). Conclusion: TXA use was associated with a significantly lower transfusion rate in patients who underwent pelvic and/or acetabular fracture surgery. Level of evidence: Level 3. Systematic review of retrospective cohort studies and prospective randomized controlled trials.

KW - Acetabulum fracture

KW - Antifibrinolysis

KW - Orthopaedic trauma

KW - Pelvic fracture

KW - Tranexamic acid

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JO - Journal of Orthopaedics

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ER -

Tranexamic acid use in pelvic and/or acetabular fracture surgery: A systematic review and meta-analysis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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