TY - JOUR
T1 - Trajectories of inflammatory markers and cognitive decline over 10 years
AU - For The Health Abc Study
AU - Metti, Andrea L.
AU - Yaffe, Kristine
AU - Boudreau, Robert M.
AU - Simonsick, Eleanor M.
AU - Carnahan, Ryan M.
AU - Satterfield, Suzanne
AU - Harris, Tamara B.
AU - Ayonayon, Hilsa N.
AU - Rosano, Caterina
AU - Cauley, Jane A.
N1 - Funding Information:
This work was supported by National Institute on Aging Contracts N01-AG-6-2101 ; N01-AG-6-2103 ; N01-AG-6-2106 ; National Institute on Aging grant R01-AG028050 and National Institute of Nursing Research grant R01-NR012459 . This research was supported in part by the Intramural Research Program on the National Institutes of Health, National Institute on Aging. Andrea Metti is supported by a National Institutes of Health Training Grant 2T32AG000181 . Andrea Metti would like to acknowledge Dr Mary Ganguli and Dr Oscar Lopez who both provided invaluable feedback and advice on this manuscript over multiple phases of its developments.
Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - We aimed to examine trajectories of inflammatory markers and cognitive decline over 10years. Cox proportional hazards models were used to examine the association between interleukin-6 and C-reactive protein (CRP) trajectory components (slope, variability, and baseline level) and cognitive decline among 1323 adults, aged 70-79years in the Health, Aging, and Body Composition Study. We tested for interactions by sex and apolipoprotein E (APOE) genotype. In models adjusted for multiple covariates and comorbidities, extreme CRP variability was significantly associated with cognitive decline (hazard ratio [HR] 1.6, 95% confidence interval [CI]: 1.1-2.3). This association was modified by sex and APOE e4 (p < 0.001 for both), such that the association remained among women (HR= 1.8; 95% CI: 1.1, 3.0) and among those with no APOE e4 allele (HR= 1.6; 95% CI: 1.1, 2.5). There were no significant associations between slope or baseline level of CRP and cognitive decline nor between interleukin-6 and cognitive decline. We believe CRP variability likely reflects poor control of or greater changes in vascular or metabolic disease over time, which in turn is associated with cognitive decline.
AB - We aimed to examine trajectories of inflammatory markers and cognitive decline over 10years. Cox proportional hazards models were used to examine the association between interleukin-6 and C-reactive protein (CRP) trajectory components (slope, variability, and baseline level) and cognitive decline among 1323 adults, aged 70-79years in the Health, Aging, and Body Composition Study. We tested for interactions by sex and apolipoprotein E (APOE) genotype. In models adjusted for multiple covariates and comorbidities, extreme CRP variability was significantly associated with cognitive decline (hazard ratio [HR] 1.6, 95% confidence interval [CI]: 1.1-2.3). This association was modified by sex and APOE e4 (p < 0.001 for both), such that the association remained among women (HR= 1.8; 95% CI: 1.1, 3.0) and among those with no APOE e4 allele (HR= 1.6; 95% CI: 1.1, 2.5). There were no significant associations between slope or baseline level of CRP and cognitive decline nor between interleukin-6 and cognitive decline. We believe CRP variability likely reflects poor control of or greater changes in vascular or metabolic disease over time, which in turn is associated with cognitive decline.
KW - C-reactive protein
KW - Cognitive decline
KW - Inflammatory markers
KW - Interleukin-6
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U2 - 10.1016/j.neurobiolaging.2014.05.030
DO - 10.1016/j.neurobiolaging.2014.05.030
M3 - Article
C2 - 24997674
AN - SCOPUS:84911367108
VL - 35
SP - 2785
EP - 2790
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 12
ER -