Trajectories of gait speed predict mortality in well-functioning older adults: The health, aging and body composition study

Daniel K. White, Tuhina Neogi, Michael C. Nevitt, Christine E. Peloquin, Yanyan Zhu, Robert M. Boudreau, Jane A. Cauley, Luigi Ferrucci, Tamara B. Harris, Susan M. Satterfield, Eleanor M. Simonsick, Elsa S. Strotmeyer, Yuqing Zhang

Research output: Contribution to journalArticle

Abstract

Background.Although gait speed slows with age, the rate of slowing varies greatly. To date, little is known about the trajectories of gait speed, their correlates, and their risk for mortality in older adults.Methods.Gait speed during a 20-m walk was measured for a period of 8 years in initially well-functioning men and women aged 70-79 years participating in the Health, Aging and Body Composition study. We described the trajectories of gait speed and examined their correlates using a group-based mixture model. Also risk associated with different gait speed trajectories on all-cause mortality was estimated using a Cox-proportional hazard model.Results.Of 2,364 participants (mean age, 73.5±2.9 years; 52% women), we identified three gait speed trajectories: slow (n 637), moderate (n 1,209), and fast decline (n 518). Those with fast decline slowed 0.030 m/s per year or 2.4% per year from baseline to the last follow-up visit. Women, blacks, and participants who were obese, had limited knee extensor strength, and had low physical activity were more likely to have fast decline than their counterparts. Participants with fast decline in gait speed had a 90% greater risk of mortality than those with slow decline.Conclusion.Despite being well-functioning at baseline, a quarter of older adults experienced fast decline in gait speed, which was associated with an increased risk of mortality.

Original languageEnglish (US)
Pages (from-to)456-464
Number of pages9
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume68
Issue number4
DOIs
StatePublished - Apr 1 2013
Externally publishedYes

Keywords

  • Gait speed
  • Mortality
  • Older adults

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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    White, D. K., Neogi, T., Nevitt, M. C., Peloquin, C. E., Zhu, Y., Boudreau, R. M., Cauley, J. A., Ferrucci, L., Harris, T. B., Satterfield, S. M., Simonsick, E. M., Strotmeyer, E. S., & Zhang, Y. (2013). Trajectories of gait speed predict mortality in well-functioning older adults: The health, aging and body composition study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 68(4), 456-464. https://doi.org/10.1093/gerona/gls197