Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis

Toshiharu Suzuki, Yoichi Araki, Tohru Yamamoto, Tadashi Nakaya

Research output: Contribution to journalShort surveypeer-review

Abstract

Alzheimer's disease (AD) is a common neurodegenerative disorder that causes senile dementia. The pathological characteristics are the appearance of neurofibrillary tangles comprising abnormally phosphorylated tau and senile plaques composed of amyloid β-protein depositions. Amyloid β-protein precursor (APP) and presenilin (PS) are known to be causative genes of familial AD. Recent analyses have documented that APP functions in the axonal transport of vesicles and PS regulates intracellular protein trafficking. Dystrophic neurites, in which APP and Alcadein accumulate in swollen axons, are also observed in AD brain. These pathological characteristics and the features of AD-related proteins suggest that AD is a disease of the vesicular transport system. Here we review recent progress of research on AD pathogenesis from the viewpoint of membrane trafficking.

Original languageEnglish (US)
Pages (from-to)949-955
Number of pages7
JournalJournal of biochemistry
Volume139
Issue number6
DOIs
StatePublished - Jun 1 2006
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid β-protein precursor
  • Cargo-receptor
  • Kinesin
  • Membrane trafficking
  • Neurodegeneration

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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