Traditional risk factors and ischemic stroke in young adults: The Baltimore-Washington cooperative young stroke study

Jennifer Rohr, Steven Kittner, Barbara Feeser, J. Richard Hebel, Marsha Gaye Whyte, Alyse Weinstein, Norma Kanarak, David Buchholz, Christopher Earley, Constance Johnson, Richard Macko, Thomas Price, Michael Sloan, Barney Stern, Robert Wityk, Marcella Wozniak, Roger Sherwin

Research output: Contribution to journalArticle

Abstract

Objective: To determine the association of hypertension, diabetes, and cigarette smoking with incidence of ischemic stroke in young adults. Designs: Case-control study. Settings Population-based sample of cases and controls. Subjects: The study included 296 cases of incident ischemic stroke among black and white adults aged 18 to 44 years in central Maryland counties from the Baltimore-Washington Cooperative Young Stroke Study and 1220 black and white adults aged 18 to 44 years from the Maryland Behavioral Risk Factor Survey, a telephone survey of a random sample of the same region, to serve as controls. Main Outcome Measures: Logistic regression models were developed to determine the age-adjusted odds ratios for each risk factor. Population- attributable risk percents were computed based on the odds ratios and prevalence of each risk factor. Results: The age-adjusted odds ratios (95% confidence intervals) for white men (WM), white women (WW), black men (BM), and black women (BW) were as follows: current cigarette smoking: WM, 2.0 (1.1-3.8), WW, 2.1 (1.1-4.3), BM, 3.3 (1.6-6.6), and BW, 2.2 (1.3-3.9); history of diabetes mellitus: WM, 22.9 (5.8-89.6), WW, 6.2 (1.9-20.2), BM, 4.2 (0.8-21.9), and BW, 3.3 (1.47.7); and history of hypertension: WM, 1.6 (0.7-3.2), WW, 2.5 (1.1-5.9), BM, 3.8 (1.8-7.9), and BW, 4.2 (2.4-7.5). The population-attributable risk percents (95% confidence intervals) were as follows: current cigarette smoking: WM, 22.6 (3.1-38.2), WW, 17.2 (4.0- 34.0), BM, 40.5 (23.154.0), and BW, 29.1 (13.5-41.9); history of diabetes mellitus: WM, 19.0 (8.2-28.5), WW, 15.8 (3.8-26.3), BM, 13.2 (5.3-20.4), and BW, 22.1 (12.5-30.7); and history of hypertension: WM, 21.7 (6.2-34.6), WW, 21.3 (5.4-34.5), BM, 53.5 (39.0-64.4), and BW, 50.5 (37.1-61.1). Conclusions: Hypertension, diabetes mellitus, and current cigarette smoking are important risk factors in a biracial young adult population. Cigarette smoking and hypertension, the 2 most modifiable risk factors, were particularly important risk factors in young blacks.

Original languageEnglish (US)
Pages (from-to)603-607
Number of pages5
JournalArchives of neurology
Volume53
Issue number7
DOIs
StatePublished - Jul 1996

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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    Rohr, J., Kittner, S., Feeser, B., Hebel, J. R., Whyte, M. G., Weinstein, A., Kanarak, N., Buchholz, D., Earley, C., Johnson, C., Macko, R., Price, T., Sloan, M., Stern, B., Wityk, R., Wozniak, M., & Sherwin, R. (1996). Traditional risk factors and ischemic stroke in young adults: The Baltimore-Washington cooperative young stroke study. Archives of neurology, 53(7), 603-607. https://doi.org/10.1001/archneur.1996.00550070041010