TY - JOUR
T1 - Traditional risk factors and ischemic stroke in young adults
T2 - The Baltimore-Washington cooperative young stroke study
AU - Rohr, Jennifer
AU - Kittner, Steven
AU - Feeser, Barbara
AU - Hebel, J. Richard
AU - Whyte, Marsha Gaye
AU - Weinstein, Alyse
AU - Kanarak, Norma
AU - Buchholz, David
AU - Earley, Christopher
AU - Johnson, Constance
AU - Macko, Richard
AU - Price, Thomas
AU - Sloan, Michael
AU - Stern, Barney
AU - Wityk, Robert J
AU - Wozniak, Marcella
AU - Sherwin, Roger
N1 - Funding Information:
supported by Dra Clinicala ClinicalStroke ResearchCenter Award (NS16332-11)and Wozniakby Investiga¬ torDevelopmentAward(K08-NS01764-01Al)fromthe Bethesda,Md.NationalInstitute ofNeurologic Disorders and Stroke,
PY - 1996/7
Y1 - 1996/7
N2 - Objective: To determine the association of hypertension, diabetes, and cigarette smoking with incidence of ischemic stroke in young adults. Designs: Case-control study. Settings Population-based sample of cases and controls. Subjects: The study included 296 cases of incident ischemic stroke among black and white adults aged 18 to 44 years in central Maryland counties from the Baltimore-Washington Cooperative Young Stroke Study and 1220 black and white adults aged 18 to 44 years from the Maryland Behavioral Risk Factor Survey, a telephone survey of a random sample of the same region, to serve as controls. Main Outcome Measures: Logistic regression models were developed to determine the age-adjusted odds ratios for each risk factor. Population- attributable risk percents were computed based on the odds ratios and prevalence of each risk factor. Results: The age-adjusted odds ratios (95% confidence intervals) for white men (WM), white women (WW), black men (BM), and black women (BW) were as follows: current cigarette smoking: WM, 2.0 (1.1-3.8), WW, 2.1 (1.1-4.3), BM, 3.3 (1.6-6.6), and BW, 2.2 (1.3-3.9); history of diabetes mellitus: WM, 22.9 (5.8-89.6), WW, 6.2 (1.9-20.2), BM, 4.2 (0.8-21.9), and BW, 3.3 (1.47.7); and history of hypertension: WM, 1.6 (0.7-3.2), WW, 2.5 (1.1-5.9), BM, 3.8 (1.8-7.9), and BW, 4.2 (2.4-7.5). The population-attributable risk percents (95% confidence intervals) were as follows: current cigarette smoking: WM, 22.6 (3.1-38.2), WW, 17.2 (4.0- 34.0), BM, 40.5 (23.154.0), and BW, 29.1 (13.5-41.9); history of diabetes mellitus: WM, 19.0 (8.2-28.5), WW, 15.8 (3.8-26.3), BM, 13.2 (5.3-20.4), and BW, 22.1 (12.5-30.7); and history of hypertension: WM, 21.7 (6.2-34.6), WW, 21.3 (5.4-34.5), BM, 53.5 (39.0-64.4), and BW, 50.5 (37.1-61.1). Conclusions: Hypertension, diabetes mellitus, and current cigarette smoking are important risk factors in a biracial young adult population. Cigarette smoking and hypertension, the 2 most modifiable risk factors, were particularly important risk factors in young blacks.
AB - Objective: To determine the association of hypertension, diabetes, and cigarette smoking with incidence of ischemic stroke in young adults. Designs: Case-control study. Settings Population-based sample of cases and controls. Subjects: The study included 296 cases of incident ischemic stroke among black and white adults aged 18 to 44 years in central Maryland counties from the Baltimore-Washington Cooperative Young Stroke Study and 1220 black and white adults aged 18 to 44 years from the Maryland Behavioral Risk Factor Survey, a telephone survey of a random sample of the same region, to serve as controls. Main Outcome Measures: Logistic regression models were developed to determine the age-adjusted odds ratios for each risk factor. Population- attributable risk percents were computed based on the odds ratios and prevalence of each risk factor. Results: The age-adjusted odds ratios (95% confidence intervals) for white men (WM), white women (WW), black men (BM), and black women (BW) were as follows: current cigarette smoking: WM, 2.0 (1.1-3.8), WW, 2.1 (1.1-4.3), BM, 3.3 (1.6-6.6), and BW, 2.2 (1.3-3.9); history of diabetes mellitus: WM, 22.9 (5.8-89.6), WW, 6.2 (1.9-20.2), BM, 4.2 (0.8-21.9), and BW, 3.3 (1.47.7); and history of hypertension: WM, 1.6 (0.7-3.2), WW, 2.5 (1.1-5.9), BM, 3.8 (1.8-7.9), and BW, 4.2 (2.4-7.5). The population-attributable risk percents (95% confidence intervals) were as follows: current cigarette smoking: WM, 22.6 (3.1-38.2), WW, 17.2 (4.0- 34.0), BM, 40.5 (23.154.0), and BW, 29.1 (13.5-41.9); history of diabetes mellitus: WM, 19.0 (8.2-28.5), WW, 15.8 (3.8-26.3), BM, 13.2 (5.3-20.4), and BW, 22.1 (12.5-30.7); and history of hypertension: WM, 21.7 (6.2-34.6), WW, 21.3 (5.4-34.5), BM, 53.5 (39.0-64.4), and BW, 50.5 (37.1-61.1). Conclusions: Hypertension, diabetes mellitus, and current cigarette smoking are important risk factors in a biracial young adult population. Cigarette smoking and hypertension, the 2 most modifiable risk factors, were particularly important risk factors in young blacks.
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U2 - 10.1001/archneur.1996.00550070041010
DO - 10.1001/archneur.1996.00550070041010
M3 - Article
C2 - 8929167
AN - SCOPUS:8944234856
SN - 0003-9942
VL - 53
SP - 603
EP - 607
JO - Archives of neurology
JF - Archives of neurology
IS - 7
ER -