Traditional Cardiovascular Risk Factors in Relation to Left Ventricular Mass, Volume, and Systolic Function by Cardiac Magnetic Resonance Imaging. The Multiethnic Study of Atherosclerosis

Susan R. Heckbert, Wendy S Post, Gregory D N Pearson, Donna K. Arnett, Antoinette S. Gomes, Michael Jerosch-Herold, W. Gregory Hundley, Joao Lima, David A. Bluemke

Research output: Contribution to journalArticle

Abstract

Objectives: The goal of this study was to examine the cross-sectional associations of cardiovascular risk factors with left ventricular (LV) geometry and systolic function measured by cardiac magnetic resonance imaging (MRI) in the Multiethnic Study of Atherosclerosis (MESA). Background: Cardiovascular risk factors including hypertension, smoking, and obesity are known to be associated with increased LV mass, but less is known about the association of risk factors with LV systolic function, particularly in populations without clinical cardiovascular disease. Methods: Participants were from 4 racial/ethnic groups and were free of clinical cardiovascular disease. Blood pressure, health habits, body mass index, lipid levels, and glucose abnormalities were assessed and MRI exams performed at baseline (n = 4,869). Multivariable linear regression was used to model the association of risk factors with LV mass, end-diastolic volume, stroke volume, ejection fraction, and cardiac output. Results: The mean age was 62 years, and 52% of the participants were women. After adjustment for sociodemographic variables and height, higher systolic blood pressure and body mass index were associated with larger LV mass and volumes. Current smoking and diabetes were associated with greater LV mass (+7.7 g, 95% confidence interval [CI] +5.5 to +9.9 and +3.5 g, 95% CI +1.2 to +5.8, respectively), and with lower stroke volume (-1.9 ml, 95% CI -3.3 to -0.5 and -4.5 ml, 95% CI -6.0 to -3.0, respectively) and lower ejection fraction (-1.6%, 95% CI -2.1 to -1.0 and -0.8%, 95% CI -1.5 to -0.2, respectively). Conclusions: In this cohort free of clinical cardiovascular disease, modifiable risk factors were associated with subclinical alterations in LV size and systolic function as detected by cardiac MRI.

Original languageEnglish (US)
Pages (from-to)2285-2292
Number of pages8
JournalJournal of the American College of Cardiology
Volume48
Issue number11
DOIs
StatePublished - Dec 5 2006

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Atherosclerosis
Magnetic Resonance Imaging
Confidence Intervals
Stroke Volume
Cardiovascular Diseases
Body Mass Index
Smoking
Blood Pressure
Hypertension
Left Ventricular Function
Ethnic Groups
Cardiac Output
Habits
Linear Models
Obesity
Lipids
Glucose
Health
Population

ASJC Scopus subject areas

  • Nursing(all)

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Traditional Cardiovascular Risk Factors in Relation to Left Ventricular Mass, Volume, and Systolic Function by Cardiac Magnetic Resonance Imaging. The Multiethnic Study of Atherosclerosis. / Heckbert, Susan R.; Post, Wendy S; Pearson, Gregory D N; Arnett, Donna K.; Gomes, Antoinette S.; Jerosch-Herold, Michael; Hundley, W. Gregory; Lima, Joao; Bluemke, David A.

In: Journal of the American College of Cardiology, Vol. 48, No. 11, 05.12.2006, p. 2285-2292.

Research output: Contribution to journalArticle

Heckbert, Susan R. ; Post, Wendy S ; Pearson, Gregory D N ; Arnett, Donna K. ; Gomes, Antoinette S. ; Jerosch-Herold, Michael ; Hundley, W. Gregory ; Lima, Joao ; Bluemke, David A. / Traditional Cardiovascular Risk Factors in Relation to Left Ventricular Mass, Volume, and Systolic Function by Cardiac Magnetic Resonance Imaging. The Multiethnic Study of Atherosclerosis. In: Journal of the American College of Cardiology. 2006 ; Vol. 48, No. 11. pp. 2285-2292.
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abstract = "Objectives: The goal of this study was to examine the cross-sectional associations of cardiovascular risk factors with left ventricular (LV) geometry and systolic function measured by cardiac magnetic resonance imaging (MRI) in the Multiethnic Study of Atherosclerosis (MESA). Background: Cardiovascular risk factors including hypertension, smoking, and obesity are known to be associated with increased LV mass, but less is known about the association of risk factors with LV systolic function, particularly in populations without clinical cardiovascular disease. Methods: Participants were from 4 racial/ethnic groups and were free of clinical cardiovascular disease. Blood pressure, health habits, body mass index, lipid levels, and glucose abnormalities were assessed and MRI exams performed at baseline (n = 4,869). Multivariable linear regression was used to model the association of risk factors with LV mass, end-diastolic volume, stroke volume, ejection fraction, and cardiac output. Results: The mean age was 62 years, and 52{\%} of the participants were women. After adjustment for sociodemographic variables and height, higher systolic blood pressure and body mass index were associated with larger LV mass and volumes. Current smoking and diabetes were associated with greater LV mass (+7.7 g, 95{\%} confidence interval [CI] +5.5 to +9.9 and +3.5 g, 95{\%} CI +1.2 to +5.8, respectively), and with lower stroke volume (-1.9 ml, 95{\%} CI -3.3 to -0.5 and -4.5 ml, 95{\%} CI -6.0 to -3.0, respectively) and lower ejection fraction (-1.6{\%}, 95{\%} CI -2.1 to -1.0 and -0.8{\%}, 95{\%} CI -1.5 to -0.2, respectively). Conclusions: In this cohort free of clinical cardiovascular disease, modifiable risk factors were associated with subclinical alterations in LV size and systolic function as detected by cardiac MRI.",
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AU - Heckbert, Susan R.

AU - Post, Wendy S

AU - Pearson, Gregory D N

AU - Arnett, Donna K.

AU - Gomes, Antoinette S.

AU - Jerosch-Herold, Michael

AU - Hundley, W. Gregory

AU - Lima, Joao

AU - Bluemke, David A.

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N2 - Objectives: The goal of this study was to examine the cross-sectional associations of cardiovascular risk factors with left ventricular (LV) geometry and systolic function measured by cardiac magnetic resonance imaging (MRI) in the Multiethnic Study of Atherosclerosis (MESA). Background: Cardiovascular risk factors including hypertension, smoking, and obesity are known to be associated with increased LV mass, but less is known about the association of risk factors with LV systolic function, particularly in populations without clinical cardiovascular disease. Methods: Participants were from 4 racial/ethnic groups and were free of clinical cardiovascular disease. Blood pressure, health habits, body mass index, lipid levels, and glucose abnormalities were assessed and MRI exams performed at baseline (n = 4,869). Multivariable linear regression was used to model the association of risk factors with LV mass, end-diastolic volume, stroke volume, ejection fraction, and cardiac output. Results: The mean age was 62 years, and 52% of the participants were women. After adjustment for sociodemographic variables and height, higher systolic blood pressure and body mass index were associated with larger LV mass and volumes. Current smoking and diabetes were associated with greater LV mass (+7.7 g, 95% confidence interval [CI] +5.5 to +9.9 and +3.5 g, 95% CI +1.2 to +5.8, respectively), and with lower stroke volume (-1.9 ml, 95% CI -3.3 to -0.5 and -4.5 ml, 95% CI -6.0 to -3.0, respectively) and lower ejection fraction (-1.6%, 95% CI -2.1 to -1.0 and -0.8%, 95% CI -1.5 to -0.2, respectively). Conclusions: In this cohort free of clinical cardiovascular disease, modifiable risk factors were associated with subclinical alterations in LV size and systolic function as detected by cardiac MRI.

AB - Objectives: The goal of this study was to examine the cross-sectional associations of cardiovascular risk factors with left ventricular (LV) geometry and systolic function measured by cardiac magnetic resonance imaging (MRI) in the Multiethnic Study of Atherosclerosis (MESA). Background: Cardiovascular risk factors including hypertension, smoking, and obesity are known to be associated with increased LV mass, but less is known about the association of risk factors with LV systolic function, particularly in populations without clinical cardiovascular disease. Methods: Participants were from 4 racial/ethnic groups and were free of clinical cardiovascular disease. Blood pressure, health habits, body mass index, lipid levels, and glucose abnormalities were assessed and MRI exams performed at baseline (n = 4,869). Multivariable linear regression was used to model the association of risk factors with LV mass, end-diastolic volume, stroke volume, ejection fraction, and cardiac output. Results: The mean age was 62 years, and 52% of the participants were women. After adjustment for sociodemographic variables and height, higher systolic blood pressure and body mass index were associated with larger LV mass and volumes. Current smoking and diabetes were associated with greater LV mass (+7.7 g, 95% confidence interval [CI] +5.5 to +9.9 and +3.5 g, 95% CI +1.2 to +5.8, respectively), and with lower stroke volume (-1.9 ml, 95% CI -3.3 to -0.5 and -4.5 ml, 95% CI -6.0 to -3.0, respectively) and lower ejection fraction (-1.6%, 95% CI -2.1 to -1.0 and -0.8%, 95% CI -1.5 to -0.2, respectively). Conclusions: In this cohort free of clinical cardiovascular disease, modifiable risk factors were associated with subclinical alterations in LV size and systolic function as detected by cardiac MRI.

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