Trachoma and antibiotic use: The A' in SAFE

Research output: Contribution to journalReview article

Abstract

Trachoma, a chronic conjunctivitis caused by Chlamydia trachomatis, is the leading infectious cause of blindness worldwide. In recognition of this public health problem, the World Health Assembly has targeted the year 2020 to eliminate blinding trachoma, and a multifaceted strategy (SAFE) is recommended, including antibiotics for treatment of infection. Trachoma is a disease of entire communities, and the pool of infection resides largely in preschool age children. Thus, for endemic communities, mass treatment with antibiotics annually for at least 3-5 years is carried out. The antibiotics used, the effectiveness of this approach, and the challenges of antibiotic treatment of communities are discussed, concluding with a view towards the elimination of trachoma in the future.

Original languageEnglish (US)
Pages (from-to)75-83
Number of pages9
JournalExpert Review of Anti-Infective Therapy
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2012

Keywords

  • Chlamydia trachomatis
  • azithromycin
  • mass treatment
  • neglected tropical disease
  • tetracycline
  • trachoma

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

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