Tracheal Occlusion for Fetal Congenital Diaphragmatic Hernia: The US Experience

Eric Jelin, Hanmin Lee

Research output: Contribution to journalReview article

Abstract

Congenital diaphragmatic hernia (CDH) is characterized by a defect in the diaphragm that permits abdominal viscera to herniate into the chest. These herniated viscera are thought to compress the growing lung and cause lung parenchymal and vascular hypoplasia. The genetic defects that cause the diaphragmatic defect may also contribute primarily to lung hypoplasia. Postnatal reduction of the herniated abdominal viscera and correction of the diaphragmatic defect are easily achievable, but the lung hypoplasia persists, often leading to persistent fetal circulation and respiratory failure. This article reviews the experimental basis of fetal therapy for CDH and the US clinical experience with tracheal occlusion.

Original languageEnglish (US)
Pages (from-to)349-361
Number of pages13
JournalClinics in Perinatology
Volume36
Issue number2
DOIs
StatePublished - Jun 1 2009
Externally publishedYes

Keywords

  • Congenital diaphragmatic hernia
  • Fetal surgery
  • Fetal tracheal occlusion
  • Lung hypoplasia
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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