TY - JOUR
T1 - TPH2 gene variants and anxiety during alcohol detoxification outcome
AU - Serretti, Alessandro
AU - Liappas, Ioannis
AU - Mandelli, Laura
AU - Albani, Diego
AU - Forloni, Gianluigi
AU - Malitas, Petros
AU - Piperi, Christina
AU - Politis, Antonis
AU - Tzavellas, Elias O.
AU - Papadopoulou-Daifoti, Zeta
AU - Zisaki, Aikaterini
AU - Prato, Francesca
AU - Batelli, Sara
AU - Polito, Letizia
AU - De Ronchi, Diana
AU - Kalofoutis, Anastasios
PY - 2009/5/15
Y1 - 2009/5/15
N2 - Clinical outcome of alcoholism may be partly under genetic control. The serotonergic system is involved in alcohol intake, and it has been widely investigated in alcohol dependence. Recently, attention has been focused on the neuronal tryptophan hydroxylase 2 gene (TPH2). TPH2 variants have been consistently associated with anxiety-related traits; since anxiety is critical for alcohol dependence treatment, in the present paper we investigated 9 SNPs within the THP2 gene in anxiety symptoms during the detoxification procedure. The sample comprised 68 alcohol-dependent patients who where evaluated with the Hamilton Rating Scale for Anxiety, before and after the detoxification procedure. Other psychopathological indicators of outcome, such as depression and anxiety sub-features were also investigated. We did not observe a role for TPH2 variants in the efficacy of treatment in relieving anxiety and other psychopathological symptoms. However, a haplotype that included the promoter rs4570625 polymorphism (associated with anxiety-related traits in previous studies) showed an association with the severity of anxiety symptoms on admission. This preliminary finding, although obtained on a small sample, may provide further support for a role of the TPH2 gene in emotional behaviors. Furthermore, the present study suggests the possible functional significance of the promoter rs4570625 polymorphism. The present preliminary results are of interest in alcoholism, given that comorbidity with anxiety represents a critical problem in treatment settings and response to detoxification.
AB - Clinical outcome of alcoholism may be partly under genetic control. The serotonergic system is involved in alcohol intake, and it has been widely investigated in alcohol dependence. Recently, attention has been focused on the neuronal tryptophan hydroxylase 2 gene (TPH2). TPH2 variants have been consistently associated with anxiety-related traits; since anxiety is critical for alcohol dependence treatment, in the present paper we investigated 9 SNPs within the THP2 gene in anxiety symptoms during the detoxification procedure. The sample comprised 68 alcohol-dependent patients who where evaluated with the Hamilton Rating Scale for Anxiety, before and after the detoxification procedure. Other psychopathological indicators of outcome, such as depression and anxiety sub-features were also investigated. We did not observe a role for TPH2 variants in the efficacy of treatment in relieving anxiety and other psychopathological symptoms. However, a haplotype that included the promoter rs4570625 polymorphism (associated with anxiety-related traits in previous studies) showed an association with the severity of anxiety symptoms on admission. This preliminary finding, although obtained on a small sample, may provide further support for a role of the TPH2 gene in emotional behaviors. Furthermore, the present study suggests the possible functional significance of the promoter rs4570625 polymorphism. The present preliminary results are of interest in alcoholism, given that comorbidity with anxiety represents a critical problem in treatment settings and response to detoxification.
KW - Alcoholism
KW - Anxiety
KW - Depression
KW - Pharmacogenetic
KW - Serotonin
UR - http://www.scopus.com/inward/record.url?scp=64649088750&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=64649088750&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2007.12.006
DO - 10.1016/j.psychres.2007.12.006
M3 - Article
C2 - 19361870
AN - SCOPUS:64649088750
SN - 0165-1781
VL - 167
SP - 106
EP - 114
JO - Psychiatry research
JF - Psychiatry research
IS - 1-2
ER -