TY - JOUR
T1 - TPA induces transglutaminase C and inhibits cell growth in the colon carcinoma cell line SW620
AU - Kósa, K.
AU - Rosenberg, M. I.
AU - Chiantore, M. V.
AU - De Luca, L. M.
PY - 1997/3/27
Y1 - 1997/3/27
N2 - In contrast to most other systems, TPA induced TG(c) activity and protein in SW620 human colon carcinoma cells. This induction was accompanied by cell growth inhibition and increased apoptosis. The general protein kinase-C inhibitor GF-109203X blocked the induction of TG(c) by TPA, whereas the specific inhibitor of the PKCα isoform, the indocarbazole Go6976, reduced it by 40%. These PKC inhibitors had similar inhibitory effects on TPA increased apoptosis and inhibition of cell growth, suggesting that the observed actions of TPA are mediated by PKC, and a close connection between TG(c) activity, increased apoptosis and cell growth inhibition. We conclude that TPA may offer new approaches in the management of colon cancer cell growth.
AB - In contrast to most other systems, TPA induced TG(c) activity and protein in SW620 human colon carcinoma cells. This induction was accompanied by cell growth inhibition and increased apoptosis. The general protein kinase-C inhibitor GF-109203X blocked the induction of TG(c) by TPA, whereas the specific inhibitor of the PKCα isoform, the indocarbazole Go6976, reduced it by 40%. These PKC inhibitors had similar inhibitory effects on TPA increased apoptosis and inhibition of cell growth, suggesting that the observed actions of TPA are mediated by PKC, and a close connection between TG(c) activity, increased apoptosis and cell growth inhibition. We conclude that TPA may offer new approaches in the management of colon cancer cell growth.
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U2 - 10.1006/bbrc.1997.6363
DO - 10.1006/bbrc.1997.6363
M3 - Article
C2 - 9126346
AN - SCOPUS:0031587775
SN - 0006-291X
VL - 232
SP - 737
EP - 741
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -