Toxoplasmosis in a group of glucose-6-phosphate dehydrogenase deficient patients

Khalid F. Tabbara, Nariman A. Sharara, Abdul Kareem Al-Momen

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: This was a retrospective study that aimed at evaluating the relative risk of Toxoplasma infection in patients with glucose-6-phosphate dehydrogenase deficiency as compared to a control group with no glucose-6-phosphate dehydrogenase deficiency. Methods: Ninety-one blood donor volunteers had serology testing from Toxoplasma gondii and were screened for glucose-6-phosphate dehydrogenase deficiency by a qualitative method using fluorescent spot test. They were all males and their ages ranged from 17 to 52 years. Results: Fifty-three persons (58%) were glucose-6-phosphate dehydrogenase deficient and 38 (42%) were glucose-6-phosphate dehydrogenase normal. In the glucose-6-phosphate dehydrogenase deficient group, 31 (58.5%) had positive titers for Toxoplasma; while in the glucose-6-phosphate dehydrogenase normal group 9 persons (24%) had positive titers for Toxoplasma. The relative risk of infection was 2.5 times more in the glucose-6-phosphate dehydrogenase deficient group, a statistically significant difference with a p value of 0.002. Conclusion: Glucose-6-phosphate dehydrogenase deficiency seems to increase the risk for Toxoplasma infection by 2.5 fold probably due to decreased killing effect, of phagocytic cells.

Original languageEnglish (US)
Pages (from-to)330-332
Number of pages3
JournalSaudi Medical Journal
Volume22
Issue number4
StatePublished - Apr 2001
Externally publishedYes

Keywords

  • Glucose-6-phosphate dehydrogenase deficiency
  • Neutrophils respiratory burst
  • Pentose monophosphate shunt
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Medicine(all)

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