Abstract
In mammalian cells, the protozoan pathogen Toxoplasma resides in a nonfusiogenic vacuole that segregates it from host cell resources. How the parasite acquires nutrients and whether it is capable of internalizing host macromolecules have been long-standing mysteries. By exploiting a mutant of Toxoplasma lacking the cathepsin protease L, Dou et al. observed the accumulation of host cytosolic-derived proteins in a multivesicular post-Golgi compartment, which establishes the existence of a functional heterophagic pathway in Toxoplasma.
Original language | English (US) |
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Pages (from-to) | 467-469 |
Number of pages | 3 |
Journal | Trends in parasitology |
Volume | 30 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1 2014 |
Keywords
- Intracellular parasitism
- Macromolecule digestion
- Nutrient uptake
- Protease cathepsins
- Toxoplasma
ASJC Scopus subject areas
- Parasitology
- Infectious Diseases