Toxoplasma, or the discovery of a heterophage

Research output: Contribution to journalShort surveypeer-review

Abstract

In mammalian cells, the protozoan pathogen Toxoplasma resides in a nonfusiogenic vacuole that segregates it from host cell resources. How the parasite acquires nutrients and whether it is capable of internalizing host macromolecules have been long-standing mysteries. By exploiting a mutant of Toxoplasma lacking the cathepsin protease L, Dou et al. observed the accumulation of host cytosolic-derived proteins in a multivesicular post-Golgi compartment, which establishes the existence of a functional heterophagic pathway in Toxoplasma.

Original languageEnglish (US)
Pages (from-to)467-469
Number of pages3
JournalTrends in parasitology
Volume30
Issue number10
DOIs
StatePublished - Oct 1 2014

Keywords

  • Intracellular parasitism
  • Macromolecule digestion
  • Nutrient uptake
  • Protease cathepsins
  • Toxoplasma

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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