Toxoplasma gondii: Survival time and variability in mouse host strains

Emeka G. Olisa; Jay Herson; Verle E. Headings; Hildrus A. Poindexter

doi:10.1016/0014-4894(77)90103-5

Toxoplasma gondii: Survival time and variability in mouse host strains

Emeka G. Olisa, Jay Herson, Verle E. Headings, Hildrus A. Poindexter

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The survival time of four strains of mice, namely Turk, Glaxo, Balb-C, and C 57 Black, inoculated with the RH strain of Toxoplasma gondii, was determined. Results obtained were analyzed to show how the "number of Toxoplasma" is related to the strain of mice and its survival time. All three effects and the interaction term were significant at level p = 0.05. The regression of the number of Toxoplasma per inoculum on log of host survival time differed significantly between Turk-Glaxo strains, and both Balb-C and C 57 Black strains. At a dose of 10,000 Toxoplasma/mm³ no difference in host strain susceptibility was apparent. The relatively superior survival time of Glaxo and Turk at increasing doses is interpreted as reflecting genetic resistance to the lethal effect of Toxoplasma. Specific evidence on this point, as well as the magnitude of the genetic effect, must await further examination.

Original language	English (US)
Pages (from-to)	307-313
Number of pages	7
Journal	Experimental Parasitology
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/0014-4894(77)90103-5
State	Published - Apr 1977
Externally published	Yes

Keywords

Host strain variability
Mouse strains: Turk, Glaxo, Balb-C, C 57 Black
Parasite
Protozoa
Survival time
Toxoplasma gondii

ASJC Scopus subject areas

Parasitology
Immunology
Infectious Diseases

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10.1016/0014-4894(77)90103-5

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title = "Toxoplasma gondii: Survival time and variability in mouse host strains",

abstract = "The survival time of four strains of mice, namely Turk, Glaxo, Balb-C, and C 57 Black, inoculated with the RH strain of Toxoplasma gondii, was determined. Results obtained were analyzed to show how the {"}number of Toxoplasma{"} is related to the strain of mice and its survival time. All three effects and the interaction term were significant at level p = 0.05. The regression of the number of Toxoplasma per inoculum on log of host survival time differed significantly between Turk-Glaxo strains, and both Balb-C and C 57 Black strains. At a dose of 10,000 Toxoplasma/mm3 no difference in host strain susceptibility was apparent. The relatively superior survival time of Glaxo and Turk at increasing doses is interpreted as reflecting genetic resistance to the lethal effect of Toxoplasma. Specific evidence on this point, as well as the magnitude of the genetic effect, must await further examination.",

keywords = "Host strain variability, Mouse strains: Turk, Glaxo, Balb-C, C 57 Black, Parasite, Protozoa, Survival time, Toxoplasma gondii",

author = "Olisa, {Emeka G.} and Jay Herson and Headings, {Verle E.} and Poindexter, {Hildrus A.}",

year = "1977",

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doi = "10.1016/0014-4894(77)90103-5",

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AU - Olisa, Emeka G.

AU - Herson, Jay

AU - Headings, Verle E.

AU - Poindexter, Hildrus A.

PY - 1977/4

Y1 - 1977/4

N2 - The survival time of four strains of mice, namely Turk, Glaxo, Balb-C, and C 57 Black, inoculated with the RH strain of Toxoplasma gondii, was determined. Results obtained were analyzed to show how the "number of Toxoplasma" is related to the strain of mice and its survival time. All three effects and the interaction term were significant at level p = 0.05. The regression of the number of Toxoplasma per inoculum on log of host survival time differed significantly between Turk-Glaxo strains, and both Balb-C and C 57 Black strains. At a dose of 10,000 Toxoplasma/mm3 no difference in host strain susceptibility was apparent. The relatively superior survival time of Glaxo and Turk at increasing doses is interpreted as reflecting genetic resistance to the lethal effect of Toxoplasma. Specific evidence on this point, as well as the magnitude of the genetic effect, must await further examination.

AB - The survival time of four strains of mice, namely Turk, Glaxo, Balb-C, and C 57 Black, inoculated with the RH strain of Toxoplasma gondii, was determined. Results obtained were analyzed to show how the "number of Toxoplasma" is related to the strain of mice and its survival time. All three effects and the interaction term were significant at level p = 0.05. The regression of the number of Toxoplasma per inoculum on log of host survival time differed significantly between Turk-Glaxo strains, and both Balb-C and C 57 Black strains. At a dose of 10,000 Toxoplasma/mm3 no difference in host strain susceptibility was apparent. The relatively superior survival time of Glaxo and Turk at increasing doses is interpreted as reflecting genetic resistance to the lethal effect of Toxoplasma. Specific evidence on this point, as well as the magnitude of the genetic effect, must await further examination.

KW - Host strain variability

KW - Mouse strains: Turk, Glaxo, Balb-C, C 57 Black

KW - Parasite

KW - Protozoa

KW - Survival time

KW - Toxoplasma gondii

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Toxoplasma gondii: Survival time and variability in mouse host strains

Abstract

Keywords

ASJC Scopus subject areas

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