Toxoplasma gondii: Survival time and variability in mouse host strains

Emeka G. Olisa, Jay Herson, Verle E. Headings, Hildrus A. Poindexter

Research output: Contribution to journalArticlepeer-review

Abstract

The survival time of four strains of mice, namely Turk, Glaxo, Balb-C, and C 57 Black, inoculated with the RH strain of Toxoplasma gondii, was determined. Results obtained were analyzed to show how the "number of Toxoplasma" is related to the strain of mice and its survival time. All three effects and the interaction term were significant at level p = 0.05. The regression of the number of Toxoplasma per inoculum on log of host survival time differed significantly between Turk-Glaxo strains, and both Balb-C and C 57 Black strains. At a dose of 10,000 Toxoplasma/mm3 no difference in host strain susceptibility was apparent. The relatively superior survival time of Glaxo and Turk at increasing doses is interpreted as reflecting genetic resistance to the lethal effect of Toxoplasma. Specific evidence on this point, as well as the magnitude of the genetic effect, must await further examination.

Original languageEnglish (US)
Pages (from-to)307-313
Number of pages7
JournalExperimental Parasitology
Volume41
Issue number2
DOIs
StatePublished - Apr 1977
Externally publishedYes

Keywords

  • Host strain variability
  • Mouse strains: Turk, Glaxo, Balb-C, C 57 Black
  • Parasite
  • Protozoa
  • Survival time
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Parasitology
  • Immunology
  • Infectious Diseases

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