Toxins of Vibrio cholerae and Escherichia coli stimulate adenyl cyclase in rat fat cells

Erik L. Hewlett; Richard L. Guerrant; Doyle J. Evans; William B. Greenough

doi:10.1038/249371a0

Toxins of Vibrio cholerae and Escherichia coli stimulate adenyl cyclase in rat fat cells

Erik L. Hewlett, Richard L. Guerrant, Doyle J. Evans, William B. Greenough

School of Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

RAT epididymal fat cells respond to enterotoxins of Vibrio cholerae and Escherichia coli with increased membrane adenyl cyclase activity and glycerol release^1-3. Cholera toxin increases adenyl cyclase activity in many other tissues and cells, including intestine, leukocytes, immunocytes, platelets and liver^4-6. Here we report studies on the response of fat cells to these bacterial toxins and their effect on membrane adenyl cyclase activation by adrenaline.

Original language	English (US)
Pages (from-to)	371-373
Number of pages	3
Journal	Nature
Volume	249
Issue number	5455
DOIs	https://doi.org/10.1038/249371a0
State	Published - Dec 1 1974

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title = "Toxins of Vibrio cholerae and Escherichia coli stimulate adenyl cyclase in rat fat cells",

abstract = "RAT epididymal fat cells respond to enterotoxins of Vibrio cholerae and Escherichia coli with increased membrane adenyl cyclase activity and glycerol release1-3. Cholera toxin increases adenyl cyclase activity in many other tissues and cells, including intestine, leukocytes, immunocytes, platelets and liver4-6. Here we report studies on the response of fat cells to these bacterial toxins and their effect on membrane adenyl cyclase activation by adrenaline.",

author = "Hewlett, {Erik L.} and Guerrant, {Richard L.} and Evans, {Doyle J.} and Greenough, {William B.}",

year = "1974",

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doi = "10.1038/249371a0",

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T1 - Toxins of Vibrio cholerae and Escherichia coli stimulate adenyl cyclase in rat fat cells

AU - Hewlett, Erik L.

AU - Guerrant, Richard L.

AU - Evans, Doyle J.

AU - Greenough, William B.

PY - 1974/12/1

Y1 - 1974/12/1

N2 - RAT epididymal fat cells respond to enterotoxins of Vibrio cholerae and Escherichia coli with increased membrane adenyl cyclase activity and glycerol release1-3. Cholera toxin increases adenyl cyclase activity in many other tissues and cells, including intestine, leukocytes, immunocytes, platelets and liver4-6. Here we report studies on the response of fat cells to these bacterial toxins and their effect on membrane adenyl cyclase activation by adrenaline.

AB - RAT epididymal fat cells respond to enterotoxins of Vibrio cholerae and Escherichia coli with increased membrane adenyl cyclase activity and glycerol release1-3. Cholera toxin increases adenyl cyclase activity in many other tissues and cells, including intestine, leukocytes, immunocytes, platelets and liver4-6. Here we report studies on the response of fat cells to these bacterial toxins and their effect on membrane adenyl cyclase activation by adrenaline.

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JO - Nature

JF - Nature

IS - 5455

ER -

Toxins of Vibrio cholerae and Escherichia coli stimulate adenyl cyclase in rat fat cells

Abstract

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