Toxins and virulence factors of enterotoxigenic Escherichia coli associated with strains isolated from indigenous children and international visitors to a rural community in Guatemala

O. R. Torres, W. González, O. Lemus, R. A. Pratdesaba, J. A. Matute, G. Wiklund, D. A. Sack, A. L. Bourgeois, A. M. Svennerholm

Research output: Contribution to journalArticlepeer-review

Abstract

Diarrhoea remains a common cause of illness in Guatemala, with children suffering most frequently from the disease. This study directly compared the frequency, enterotoxin, and colonization factor (CF) profiles of enterotoxigenic Escherichia coli (ETEC) strains isolated from children living in a rural community in Guatemala and from Western visitors to the same location during the same seasons, using similar detection methodologies. We found that ETEC accounted for 26% of severe cases of diarrhoea in children requiring hospitalization, 15% of diarrhoea in the community, and 29% of travellers' diarrhoea in visitors staying ≥2 weeks. The toxin and CF patterns of the ETEC strains isolated from both groups differed significantly (P < 0·0005) as determined by χ2 = 60·39 for CFs and χ2 = 35 for toxins, while ETEC phenotypes found in Guatemalan children were comparable to those found in children from other areas of the world.

Original languageEnglish (US)
Pages (from-to)1662-1671
Number of pages10
JournalEpidemiology and infection
Volume143
Issue number8
DOIs
StatePublished - Mar 15 2015

Keywords

  • Diarrhoea
  • Escherichia coli
  • enteric bacteria
  • enterotoxin
  • travellers' infection

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases

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