Toxicodynamics and long-term toxicity of the recreational drug, 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy')

Research output: Contribution to journalArticlepeer-review

Abstract

The recreational drug, (±)3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), is a potent serotonin (5-HT) neurotoxin in animals. Whether humans who use MDMA incur 5-HT neural injury is unknown. The present studies utilized positron emission tomography (PET) in conjunction with the 5-HT transporter ligand, [11C]McN-5652 to assess the status of brain 5-HT neurons in human MDMA users. Like nonhuman primates treated with neurotoxic doses of MDMA, humans with a history of MDMA use showed lasting decrements in global brain [11C]McN-5652 binding, with decreases in [11C]McN-5652 binding positively correlated to the extent of previous MDMA use. These results suggest that human MDMA use results in brain 5-HT neurotoxicity. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalToxicology Letters
Volume112-113
DOIs
StatePublished - Mar 15 2000

Keywords

  • 3,4-Methylenedioxy-methamphetamine
  • Amphetamines
  • Neurotoxicity
  • PET
  • Serotonin
  • Transporters

ASJC Scopus subject areas

  • Toxicology

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