Toxic-Therapeutic Ratio of Sodium Cyanate

Samuel Charache, Thomas P. Duffy, Nancy Jander, Jean C. Scott, Marshall Bedine, Roger Morrell

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Six patients with sickle cell anemia were treated with sodium cyanate (30 mg/ kg/day). In four, treatment was stopped because of definite or suspected toxicity, and no improvement was seen in the other two. Most alarming was the sudden development of a peripheral motor neuropathy in a patient whose red blood cells contained less than 0.6 mols NCO /mol of hemoglobin; six months after treatment was stopped, function had not completely returned in this patient. Safe oral dosage regimens may not be effective, but extracorporeal treatment of sickle cells with cyanate, or other compounds, might circumvent that problem.

Original languageEnglish (US)
Pages (from-to)1043-1047
Number of pages5
JournalArchives of internal medicine
Issue number8
StatePublished - Aug 1975

ASJC Scopus subject areas

  • Internal Medicine


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