Toxic neuropathies: Chemotherapy induced peripheral neurotoxicity

Paola Alberti, Guido Cavaletti, David R. Cornblath

Research output: Contribution to journalReview article

Abstract

Purpose of reviewChemotherapy-induced peripheral neurotoxicity (CIPN) is a common and distressing side-effect of many chemotherapy regimens. Currently, aside from symptomatic treatments for neuropathic pain, there are no treatments to prevent CIPN or treat established CIPN. We discuss recent articles addressing clinimetric issues and treatment of CIPN.Recent findingsThere are important clinimetric issues that need to be addressed so that robust clinical trials in CIPN can be performed. There are new compounds in early development that may treat CIPN, but larger studies are needed.SummaryA multidisciplinary, international approach is needed to unravel CIPN; the Toxic Neuropathy Consortium (TNC) of the Peripheral Nerve Society may be the home for such efforts.

Original languageEnglish (US)
Pages (from-to)676-683
Number of pages8
JournalCurrent opinion in neurology
Volume32
Issue number5
DOIs
StatePublished - Oct 1 2019

Keywords

  • chemotherapy-induced peripheral neurotoxicity
  • clinical trials
  • clinimetric endpoint
  • patient-reported outcome measure
  • toxic neuropathy consortium

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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