Toxic environmental exposures and kidney health in children

Darcy K. Weidemann; Virginia M. Weaver; Jeffrey J. Fadrowski

doi:10.1007/s00467-015-3222-3

Toxic environmental exposures and kidney health in children

Darcy K. Weidemann, Virginia M. Weaver, Jeffrey J. Fadrowski

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

High-level exposures to a number of agents are known to have direct nephrotoxic effects in children. A growing body of literature supports the hypothesis that chronic, relatively low-level exposure to various nephrotoxicants may also increase the risk for chronic kidney disease (CKD) or accelerate its progression. In this review we highlight several environmental nephrotoxicants and their association with CKD in children and adolescents. We also discuss unique epidemiological challenges in the use of kidney biomarkers in environmental nephrotoxicology.

Original language	English (US)
Pages (from-to)	2043-2054
Number of pages	12
Journal	Pediatric Nephrology
Volume	31
Issue number	11
DOIs	https://doi.org/10.1007/s00467-015-3222-3
State	Published - Nov 1 2016

Keywords

Aristolochic acid
Arsenic
Cadmium
Chronic kidney disease
Environmental nephrotoxicants
Lead
Melamine

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Nephrology

Access to Document

10.1007/s00467-015-3222-3

Cite this

@article{39606a2d8fa140e692a3f32a7c7f9b4b,

title = "Toxic environmental exposures and kidney health in children",

abstract = "High-level exposures to a number of agents are known to have direct nephrotoxic effects in children. A growing body of literature supports the hypothesis that chronic, relatively low-level exposure to various nephrotoxicants may also increase the risk for chronic kidney disease (CKD) or accelerate its progression. In this review we highlight several environmental nephrotoxicants and their association with CKD in children and adolescents. We also discuss unique epidemiological challenges in the use of kidney biomarkers in environmental nephrotoxicology.",

keywords = "Aristolochic acid, Arsenic, Cadmium, Chronic kidney disease, Environmental nephrotoxicants, Lead, Melamine",

author = "Weidemann, {Darcy K.} and Weaver, {Virginia M.} and Fadrowski, {Jeffrey J.}",

note = "Publisher Copyright: {\textcopyright} 2015, IPNA.",

year = "2016",

month = nov,

day = "1",

doi = "10.1007/s00467-015-3222-3",

language = "English (US)",

volume = "31",

pages = "2043--2054",

journal = "Pediatric Nephrology",

issn = "0931-041X",

publisher = "Springer Verlag",

number = "11",

}

TY - JOUR

T1 - Toxic environmental exposures and kidney health in children

AU - Weidemann, Darcy K.

AU - Weaver, Virginia M.

AU - Fadrowski, Jeffrey J.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - High-level exposures to a number of agents are known to have direct nephrotoxic effects in children. A growing body of literature supports the hypothesis that chronic, relatively low-level exposure to various nephrotoxicants may also increase the risk for chronic kidney disease (CKD) or accelerate its progression. In this review we highlight several environmental nephrotoxicants and their association with CKD in children and adolescents. We also discuss unique epidemiological challenges in the use of kidney biomarkers in environmental nephrotoxicology.

AB - High-level exposures to a number of agents are known to have direct nephrotoxic effects in children. A growing body of literature supports the hypothesis that chronic, relatively low-level exposure to various nephrotoxicants may also increase the risk for chronic kidney disease (CKD) or accelerate its progression. In this review we highlight several environmental nephrotoxicants and their association with CKD in children and adolescents. We also discuss unique epidemiological challenges in the use of kidney biomarkers in environmental nephrotoxicology.

KW - Aristolochic acid

KW - Arsenic

KW - Cadmium

KW - Chronic kidney disease

KW - Environmental nephrotoxicants

KW - Lead

KW - Melamine

UR - http://www.scopus.com/inward/record.url?scp=84944522371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944522371&partnerID=8YFLogxK

U2 - 10.1007/s00467-015-3222-3

DO - 10.1007/s00467-015-3222-3

M3 - Article

C2 - 26458883

AN - SCOPUS:84944522371

SN - 0931-041X

VL - 31

SP - 2043

EP - 2054

JO - Pediatric Nephrology

JF - Pediatric Nephrology

IS - 11

ER -

Toxic environmental exposures and kidney health in children

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this