TY - JOUR
T1 - Towards the genetic control of insect vectors
T2 - An overview
AU - Abraham, Eappen G.
AU - Cha, Sung Jae
AU - Jacobs-Lorena, Marcelo
PY - 2007/12
Y1 - 2007/12
N2 - Insects are responsible for the transmission of major infectious diseases. Recent advances in insect genomics and transformation technology provide new strategies for the control of insect borne pathogen transmission and insect pest management. One such strategy is the genetic modification of insects with genes that block pathogen development. Another is to suppress insect populations by releasing either sterile males or males carrying female-specific dominant lethal genes into the environment. Although significant progress has been made in the laboratory, further research is needed to extend these approaches to the field. These insect control strategies offer several advantages over conventional insecticide-based strategies. However, the release of genetically modified insects into the environment should proceed with great caution, after ensuring its safety, and acceptance by the target populations.
AB - Insects are responsible for the transmission of major infectious diseases. Recent advances in insect genomics and transformation technology provide new strategies for the control of insect borne pathogen transmission and insect pest management. One such strategy is the genetic modification of insects with genes that block pathogen development. Another is to suppress insect populations by releasing either sterile males or males carrying female-specific dominant lethal genes into the environment. Although significant progress has been made in the laboratory, further research is needed to extend these approaches to the field. These insect control strategies offer several advantages over conventional insecticide-based strategies. However, the release of genetically modified insects into the environment should proceed with great caution, after ensuring its safety, and acceptance by the target populations.
KW - Conditional gene expression
KW - Insect genetic control
KW - Sterile insect technology
KW - Transposable element
KW - Vector borne disease
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U2 - 10.1111/j.1748-5967.2007.00117.x
DO - 10.1111/j.1748-5967.2007.00117.x
M3 - Review article
C2 - 25530773
AN - SCOPUS:36649036791
SN - 1738-2297
VL - 37
SP - 213
EP - 220
JO - Entomological Research
JF - Entomological Research
IS - 4
ER -