Towards real-time intravascular endoscopic magnetic resonance imaging

Shashank Sathyanarayana, Michael Schr, Dara L. Kraitchman, Paul A. Bottomley

Research output: Contribution to journalReview article

Abstract

Fast, minimally invasive, high-resolution intravascular imaging is essential for identifying vascular pathological features and for developing novel diagnostic tools and treatments. Intravascular magnetic resonance imaging (MRI) with active internal probes offers high sensitivity to pathological features without ionizing radiation or the limited luminal views of conventional X-rays, but has been unable to provide a high-speed, high-resolution, endoscopic view. Herein, real-time MRI endoscopy is introduced for performing MRI from a viewpoint intrinsically locked to a miniature active, internal transmitterreceiver in a clinical 3.0-T MRI scanner. Real-time MRI endoscopy at up to 2 frames/s depicts vascular wall morphological features, atherosclerosis, and calcification at 80 to 300 μm resolution during probe advancement through diseased human iliac artery specimens and atherosclerotic rabbit aortas in vivo. MRI endoscopy offers the potential for fast, minimally invasive, transluminal, high-resolution imaging of vascular disease on a common clinical platform suitable for evaluating and targeting atherosclerosis in both experimental and clinical settings.

Original languageEnglish (US)
Pages (from-to)1158-1165
Number of pages8
JournalJACC: Cardiovascular Imaging
Volume3
Issue number11
DOIs
StatePublished - Nov 2010

Keywords

  • CT
  • FA
  • FOV
  • MRI
  • OD
  • RF
  • SNR
  • computed tomography
  • field of view
  • flip angle
  • magnetic resonance imaging
  • outer diameter
  • radiofrequency
  • signal-to-noise ratio

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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