Towards quality assurance and quality control in untargeted metabolomics studies

Richard D. Beger; Warwick B. Dunn; Abbas Bandukwala; Bianca Bethan; David Broadhurst; Clary B. Clish; Surendra Dasari; Leslie Derr; Annie Evans; Steve Fischer; Thomas Flynn; Thomas Hartung; David Herrington; Richard Higashi; Ping Ching Hsu; Christina Jones; Maureen Kachman; Helen Karuso; Gary Kruppa; Katrice Lippa; Padma Maruvada; Jonathan Mosley; Ioanna Ntai; Claire O’Donovan; Mary Playdon; Daniel Raftery; Daniel Shaughnessy; Amanda Souza; Timothy Spaeder; Barbara Spalholz; Fariba Tayyari; Baljit Ubhi; Mukesh Verma; Tilman Walk; Ian Wilson; Keren Witkin; Daniel W. Bearden; Krista A. Zanetti

doi:10.1007/s11306-018-1460-7

Towards quality assurance and quality control in untargeted metabolomics studies

Richard D. Beger, Warwick B. Dunn, Abbas Bandukwala, Bianca Bethan, David Broadhurst, Clary B. Clish, Surendra Dasari, Leslie Derr, Annie Evans, Steve Fischer, Thomas Flynn, Thomas Hartung, David Herrington, Richard Higashi, Ping Ching Hsu, Christina Jones, Maureen Kachman, Helen Karuso, Gary Kruppa, Katrice LippaPadma Maruvada, Jonathan Mosley, Ioanna Ntai, Claire O’Donovan, Mary Playdon, Daniel Raftery, Daniel Shaughnessy, Amanda Souza, Timothy Spaeder, Barbara Spalholz, Fariba Tayyari, Baljit Ubhi, Mukesh Verma, Tilman Walk, Ian Wilson, Keren Witkin, Daniel W. Bearden, Krista A. Zanetti

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

We describe here the agreed upon first development steps and priority objectives of a community engagement effort to address current challenges in quality assurance (QA) and quality control (QC) in untargeted metabolomic studies. This has included (1) a QA and QC questionnaire responded to by the metabolomics community in 2015 which recommended education of the metabolomics community, development of appropriate standard reference materials and providing incentives for laboratories to apply QA and QC; (2) a 2-day ‘Think Tank on Quality Assurance and Quality Control for Untargeted Metabolomic Studies’ held at the National Cancer Institute’s Shady Grove Campus and (3) establishment of the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) to drive forward developments in a coordinated manner.

Original language	English (US)
Article number	4
Journal	Metabolomics
Volume	15
Issue number	1
DOIs	https://doi.org/10.1007/s11306-018-1460-7
State	Published - Jan 1 2019

Keywords

Community engagement
Quality assurance (QA)
Quality control (QC)
Reporting metrics
Test materials

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Clinical Biochemistry

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Beger, R. D., Dunn, W. B., Bandukwala, A., Bethan, B., Broadhurst, D., Clish, C. B., Dasari, S., Derr, L., Evans, A., Fischer, S., Flynn, T., Hartung, T., Herrington, D., Higashi, R., Hsu, P. C., Jones, C., Kachman, M., Karuso, H., Kruppa, G., ... Zanetti, K. A. (2019). Towards quality assurance and quality control in untargeted metabolomics studies. Metabolomics, 15(1), Article 4. https://doi.org/10.1007/s11306-018-1460-7

Beger, RD, Dunn, WB, Bandukwala, A, Bethan, B, Broadhurst, D, Clish, CB, Dasari, S, Derr, L, Evans, A, Fischer, S, Flynn, T, Hartung, T, Herrington, D, Higashi, R, Hsu, PC, Jones, C, Kachman, M, Karuso, H, Kruppa, G, Lippa, K, Maruvada, P, Mosley, J, Ntai, I, O’Donovan, C, Playdon, M, Raftery, D, Shaughnessy, D, Souza, A, Spaeder, T, Spalholz, B, Tayyari, F, Ubhi, B, Verma, M, Walk, T, Wilson, I, Witkin, K, Bearden, DW & Zanetti, KA 2019, 'Towards quality assurance and quality control in untargeted metabolomics studies', Metabolomics, vol. 15, no. 1, 4. https://doi.org/10.1007/s11306-018-1460-7

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abstract = "We describe here the agreed upon first development steps and priority objectives of a community engagement effort to address current challenges in quality assurance (QA) and quality control (QC) in untargeted metabolomic studies. This has included (1) a QA and QC questionnaire responded to by the metabolomics community in 2015 which recommended education of the metabolomics community, development of appropriate standard reference materials and providing incentives for laboratories to apply QA and QC; (2) a 2-day {\textquoteleft}Think Tank on Quality Assurance and Quality Control for Untargeted Metabolomic Studies{\textquoteright} held at the National Cancer Institute{\textquoteright}s Shady Grove Campus and (3) establishment of the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) to drive forward developments in a coordinated manner.",

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AU - Broadhurst, David

AU - Clish, Clary B.

AU - Dasari, Surendra

AU - Derr, Leslie

AU - Evans, Annie

AU - Fischer, Steve

AU - Flynn, Thomas

AU - Hartung, Thomas

AU - Herrington, David

AU - Higashi, Richard

AU - Hsu, Ping Ching

AU - Jones, Christina

AU - Kachman, Maureen

AU - Karuso, Helen

AU - Kruppa, Gary

AU - Lippa, Katrice

AU - Maruvada, Padma

AU - Mosley, Jonathan

AU - Ntai, Ioanna

AU - O’Donovan, Claire

AU - Playdon, Mary

AU - Raftery, Daniel

AU - Shaughnessy, Daniel

AU - Souza, Amanda

AU - Spaeder, Timothy

AU - Spalholz, Barbara

AU - Tayyari, Fariba

AU - Ubhi, Baljit

AU - Verma, Mukesh

AU - Walk, Tilman

AU - Wilson, Ian

AU - Witkin, Keren

AU - Bearden, Daniel W.

AU - Zanetti, Krista A.

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Towards quality assurance and quality control in untargeted metabolomics studies

Abstract

Keywords

ASJC Scopus subject areas

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