Towards quality assurance and quality control in untargeted metabolomics studies

Richard D. Beger, Warwick B. Dunn, Abbas Bandukwala, Bianca Bethan, David Broadhurst, Clary B. Clish, Surendra Dasari, Leslie Derr, Annie Evans, Steve Fischer, Thomas Flynn, Thomas Hartung, David Herrington, Richard Higashi, Ping Ching Hsu, Christina Jones, Maureen Kachman, Helen Karuso, Gary Kruppa, Katrice Lippa & 18 others Padma Maruvada, Jonathan Mosley, Ioanna Ntai, Claire O’Donovan, Mary Playdon, Daniel Raftery, Daniel Shaughnessy, Amanda Souza, Timothy Spaeder, Barbara Spalholz, Fariba Tayyari, Baljit Ubhi, Mukesh Verma, Tilman Walk, Ian Wilson, Keren Witkin, Daniel W. Bearden, Krista A. Zanetti

Research output: Contribution to journalArticle

Abstract

We describe here the agreed upon first development steps and priority objectives of a community engagement effort to address current challenges in quality assurance (QA) and quality control (QC) in untargeted metabolomic studies. This has included (1) a QA and QC questionnaire responded to by the metabolomics community in 2015 which recommended education of the metabolomics community, development of appropriate standard reference materials and providing incentives for laboratories to apply QA and QC; (2) a 2-day ‘Think Tank on Quality Assurance and Quality Control for Untargeted Metabolomic Studies’ held at the National Cancer Institute’s Shady Grove Campus and (3) establishment of the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) to drive forward developments in a coordinated manner.

Original languageEnglish (US)
Article number4
JournalMetabolomics
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2019

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Metabolomics
Quality assurance
Quality Control
Quality control
Social Planning
National Cancer Institute (U.S.)
Motivation
Education

Keywords

  • Community engagement
  • Quality assurance (QA)
  • Quality control (QC)
  • Reporting metrics
  • Test materials

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry

Cite this

Beger, R. D., Dunn, W. B., Bandukwala, A., Bethan, B., Broadhurst, D., Clish, C. B., ... Zanetti, K. A. (2019). Towards quality assurance and quality control in untargeted metabolomics studies. Metabolomics, 15(1), [4]. https://doi.org/10.1007/s11306-018-1460-7

Towards quality assurance and quality control in untargeted metabolomics studies. / Beger, Richard D.; Dunn, Warwick B.; Bandukwala, Abbas; Bethan, Bianca; Broadhurst, David; Clish, Clary B.; Dasari, Surendra; Derr, Leslie; Evans, Annie; Fischer, Steve; Flynn, Thomas; Hartung, Thomas; Herrington, David; Higashi, Richard; Hsu, Ping Ching; Jones, Christina; Kachman, Maureen; Karuso, Helen; Kruppa, Gary; Lippa, Katrice; Maruvada, Padma; Mosley, Jonathan; Ntai, Ioanna; O’Donovan, Claire; Playdon, Mary; Raftery, Daniel; Shaughnessy, Daniel; Souza, Amanda; Spaeder, Timothy; Spalholz, Barbara; Tayyari, Fariba; Ubhi, Baljit; Verma, Mukesh; Walk, Tilman; Wilson, Ian; Witkin, Keren; Bearden, Daniel W.; Zanetti, Krista A.

In: Metabolomics, Vol. 15, No. 1, 4, 01.01.2019.

Research output: Contribution to journalArticle

Beger, RD, Dunn, WB, Bandukwala, A, Bethan, B, Broadhurst, D, Clish, CB, Dasari, S, Derr, L, Evans, A, Fischer, S, Flynn, T, Hartung, T, Herrington, D, Higashi, R, Hsu, PC, Jones, C, Kachman, M, Karuso, H, Kruppa, G, Lippa, K, Maruvada, P, Mosley, J, Ntai, I, O’Donovan, C, Playdon, M, Raftery, D, Shaughnessy, D, Souza, A, Spaeder, T, Spalholz, B, Tayyari, F, Ubhi, B, Verma, M, Walk, T, Wilson, I, Witkin, K, Bearden, DW & Zanetti, KA 2019, 'Towards quality assurance and quality control in untargeted metabolomics studies', Metabolomics, vol. 15, no. 1, 4. https://doi.org/10.1007/s11306-018-1460-7
Beger RD, Dunn WB, Bandukwala A, Bethan B, Broadhurst D, Clish CB et al. Towards quality assurance and quality control in untargeted metabolomics studies. Metabolomics. 2019 Jan 1;15(1). 4. https://doi.org/10.1007/s11306-018-1460-7
Beger, Richard D. ; Dunn, Warwick B. ; Bandukwala, Abbas ; Bethan, Bianca ; Broadhurst, David ; Clish, Clary B. ; Dasari, Surendra ; Derr, Leslie ; Evans, Annie ; Fischer, Steve ; Flynn, Thomas ; Hartung, Thomas ; Herrington, David ; Higashi, Richard ; Hsu, Ping Ching ; Jones, Christina ; Kachman, Maureen ; Karuso, Helen ; Kruppa, Gary ; Lippa, Katrice ; Maruvada, Padma ; Mosley, Jonathan ; Ntai, Ioanna ; O’Donovan, Claire ; Playdon, Mary ; Raftery, Daniel ; Shaughnessy, Daniel ; Souza, Amanda ; Spaeder, Timothy ; Spalholz, Barbara ; Tayyari, Fariba ; Ubhi, Baljit ; Verma, Mukesh ; Walk, Tilman ; Wilson, Ian ; Witkin, Keren ; Bearden, Daniel W. ; Zanetti, Krista A. / Towards quality assurance and quality control in untargeted metabolomics studies. In: Metabolomics. 2019 ; Vol. 15, No. 1.
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