Towards high-throughput 3D tissue fabrication using cell sheet engineering and magmetic levitation

Nisa Penland, Mikael Perla, Alex Jiao, Deok Ho Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

One of the current challenges in tissue engineering is to produce functional 3D tissue models which recapitulate complex, physiological structures; often, these structures ultimately determine tissue function. To address this, we previously developed platforms to engineer aligned tissues with improved function and structurally organized, scaffold-free 3D tissues. However, a high-throughput method to produce 3D tissues would allow for scalability of our platform for applications in drug screening and disease modeling. Towards this goal, here we report a new method for producing structured three-dimensional tissue enabled by combining our thermoresponsive, nanofabricated substrata (TNFS) and magnetic cell levitation using iron oxide nanoparticles.

Original languageEnglish (US)
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages585-587
Number of pages3
ISBN (Electronic)9780979806483
StatePublished - 2015
Externally publishedYes
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: Oct 25 2015Oct 29 2015

Publication series

NameMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period10/25/1510/29/15

Keywords

  • Cell sheet engineering
  • Magnetic levitation
  • Nanoparticles
  • Tissue engineering

ASJC Scopus subject areas

  • Control and Systems Engineering

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