TY - GEN
T1 - Towards high-throughput 3D tissue fabrication using cell sheet engineering and magmetic levitation
AU - Penland, Nisa
AU - Perla, Mikael
AU - Jiao, Alex
AU - Kim, Deok Ho
N1 - Publisher Copyright:
© 15CBMS-0001.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2015
Y1 - 2015
N2 - One of the current challenges in tissue engineering is to produce functional 3D tissue models which recapitulate complex, physiological structures; often, these structures ultimately determine tissue function. To address this, we previously developed platforms to engineer aligned tissues with improved function and structurally organized, scaffold-free 3D tissues. However, a high-throughput method to produce 3D tissues would allow for scalability of our platform for applications in drug screening and disease modeling. Towards this goal, here we report a new method for producing structured three-dimensional tissue enabled by combining our thermoresponsive, nanofabricated substrata (TNFS) and magnetic cell levitation using iron oxide nanoparticles.
AB - One of the current challenges in tissue engineering is to produce functional 3D tissue models which recapitulate complex, physiological structures; often, these structures ultimately determine tissue function. To address this, we previously developed platforms to engineer aligned tissues with improved function and structurally organized, scaffold-free 3D tissues. However, a high-throughput method to produce 3D tissues would allow for scalability of our platform for applications in drug screening and disease modeling. Towards this goal, here we report a new method for producing structured three-dimensional tissue enabled by combining our thermoresponsive, nanofabricated substrata (TNFS) and magnetic cell levitation using iron oxide nanoparticles.
KW - Cell sheet engineering
KW - Magnetic levitation
KW - Nanoparticles
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84983339573&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983339573&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84983339573
T3 - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 585
EP - 587
BT - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Y2 - 25 October 2015 through 29 October 2015
ER -