TY - JOUR
T1 - Towards cracking the code
T2 - LIM protein complexes in the spinal cord
AU - Sockanathan, Shanthini
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - Combinatorial transcription codes are used widely in the developing nervous system to specify the development of many distinct cell types. Although this strategy maximizes the use of small numbers of proteins, the molecular basis for imposing specificity remains unclear. A recent study has addressed this question by demonstrating that the favoring of hexameric complexes of specific LIM homeodomain proteins over tetramers could dictate the choice between motor neuron versus interneuron fate.
AB - Combinatorial transcription codes are used widely in the developing nervous system to specify the development of many distinct cell types. Although this strategy maximizes the use of small numbers of proteins, the molecular basis for imposing specificity remains unclear. A recent study has addressed this question by demonstrating that the favoring of hexameric complexes of specific LIM homeodomain proteins over tetramers could dictate the choice between motor neuron versus interneuron fate.
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UR - http://www.scopus.com/inward/citedby.url?scp=0037302516&partnerID=8YFLogxK
U2 - 10.1016/S0166-2236(02)00029-2
DO - 10.1016/S0166-2236(02)00029-2
M3 - Short survey
C2 - 12536126
AN - SCOPUS:0037302516
SN - 0166-2236
VL - 26
SP - 57
EP - 59
JO - Trends in neurosciences
JF - Trends in neurosciences
IS - 2
ER -