Abstract
Matrix metalloproteinases (MMPs) have been identified as biomarkers for cancer, offering prognostic potential; however, non-invasive detection protocols are currently lacking. Herein, we describe the synthesis of a DOTA-containing peptide sequence that can be radiolabelled easily with 68Gallium or can be incorporated with gadolinium for possible MRI applications with clear selectivity for MMP-2 over other members of the MMP family, giving MMP-2 selective cleavage of the labelled peptides.
Original language | English (US) |
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Pages (from-to) | 1530-1534 |
Number of pages | 5 |
Journal | Dalton Transactions |
Volume | 47 |
Issue number | 5 |
DOIs | |
State | Published - 2018 |
Externally published | Yes |
ASJC Scopus subject areas
- Inorganic Chemistry