Towards an MMP-2-activated molecular agent for cancer imaging

S. Cowell, Laurence Carroll, I. Lavdas, E. O. Aboagye, R. Vilar

Research output: Contribution to journalArticle

Abstract

Matrix metalloproteinases (MMPs) have been identified as biomarkers for cancer, offering prognostic potential; however, non-invasive detection protocols are currently lacking. Herein, we describe the synthesis of a DOTA-containing peptide sequence that can be radiolabelled easily with 68Gallium or can be incorporated with gadolinium for possible MRI applications with clear selectivity for MMP-2 over other members of the MMP family, giving MMP-2 selective cleavage of the labelled peptides.

Original languageEnglish (US)
Pages (from-to)1530-1534
Number of pages5
JournalDalton Transactions
Volume47
Issue number5
DOIs
Publication statusPublished - Jan 1 2018
Externally publishedYes

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ASJC Scopus subject areas

  • Inorganic Chemistry

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