Towards an HIV-1 cure

Measuring the latent reservoir

Katherine M. Bruner, Nina N. Hosmane, Robert F Siliciano

Research output: Contribution to journalArticle

Abstract

The latent reservoir (LR) of HIV-1 in resting memory CD4+ T cells serves as a major barrier to curing HIV-1 infection. While many PCR- and culture-based assays have been used to measure the size of the LR, correlation between results of different assays is poor and recent studies indicate that no available assay provides an accurate measurement of reservoir size. The discrepancies between assays are a hurdle to clinical trials that aim to measure the efficacy of HIV-1 eradication strategies. Here we describe the advantages and disadvantages of various approaches to measuring the LR.

Original languageEnglish (US)
Pages (from-to)192-203
Number of pages12
JournalTrends in Microbiology
Volume23
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

HIV-1
HIV Infections
Clinical Trials
T-Lymphocytes
Polymerase Chain Reaction

Keywords

  • Assays
  • Cure
  • HIV-1
  • Latency

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology
  • Medicine(all)

Cite this

Towards an HIV-1 cure : Measuring the latent reservoir. / Bruner, Katherine M.; Hosmane, Nina N.; Siliciano, Robert F.

In: Trends in Microbiology, Vol. 23, No. 4, 01.04.2015, p. 192-203.

Research output: Contribution to journalArticle

Bruner, Katherine M. ; Hosmane, Nina N. ; Siliciano, Robert F. / Towards an HIV-1 cure : Measuring the latent reservoir. In: Trends in Microbiology. 2015 ; Vol. 23, No. 4. pp. 192-203.
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