Towards a molecular understanding of cytokinesis

Douglas N. Robinson, James A. Spudich

Research output: Contribution to journalReview articlepeer-review

150 Scopus citations


In this review, we focus on recent discoveries regarding the molecular basis of cleavage furrow positioning and contractile ring assembly and contraction during cytokinesis. However, some of these mechanisms might have different degrees of importance in different organisms. This synthesis attempts to uncover common themes and to reveal potential relationships that might contribute to the biochemical and mechanical aspects of cytokinesis. Because the information about cytokinesis is still fairly rudimentary, our goal is not to present a definitive model but to present testable hypotheses that might lead to a better mechanistic understanding of the process. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)228-237
Number of pages10
JournalTrends in Cell Biology
Issue number6
StatePublished - Jun 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


Dive into the research topics of 'Towards a molecular understanding of cytokinesis'. Together they form a unique fingerprint.

Cite this