Towards a molecular pathway for myoblast fusion in Drosophila

Elizabeth H. Chen, Eric N. Olson

Research output: Contribution to journalArticlepeer-review

Abstract

Intercellular fusion among myoblasts is required for the generation of multinucleated muscle fibers during skeletal muscle development. Recent studies in Drosophila have shed light on the molecular mechanisms that underlie this process, and a signaling pathway that relays fusion signals from the cell membrane to the cytoskeleton has emerged. In this article, we review these recent advances and discuss how Drosophila offers a powerful model system to study myoblast fusion in vivo.

Original languageEnglish (US)
Pages (from-to)452-460
Number of pages9
JournalTrends in Cell Biology
Volume14
Issue number8
DOIs
StatePublished - Aug 2004

ASJC Scopus subject areas

  • Cell Biology

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