Towards a gene expression biomarker set for human biological age

Alice C. Holly; David Melzer; Luke C. Pilling; William Henley; Dena G. Hernandez; Andrew B. Singleton; Stefania Bandinelli; Jack M. Guralnik; Luigi Ferrucci; Lorna W. Harries

doi:10.1111/acel.12044

Towards a gene expression biomarker set for human biological age

Alice C. Holly, David Melzer, Luke C. Pilling, William Henley, Dena G. Hernandez, Andrew B. Singleton, Stefania Bandinelli, Jack M. Guralnik, Luigi Ferrucci, Lorna W. Harries

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

We have previously described a statistical model capable of distinguishing young (age -2, 3.5 3 10^-4, 1.8 3 10^-2, 1.5 3 10^-2, respectively). We conclude that our expression signature of age is robust across three populations and may have utility for estimation of biological age.

Original language	English (US)
Pages (from-to)	324-326
Number of pages	3
Journal	Aging Cell
Volume	12
Issue number	2
DOIs	https://doi.org/10.1111/acel.12044
State	Published - 2013
Externally published	Yes

Keywords

Biological aging
Cell senescence
Mrna expression
Predictive model.

ASJC Scopus subject areas

Cell Biology
Aging

Access to Document

10.1111/acel.12044

Cite this

@article{e751e87c1447454d93ed143d04949328,

title = "Towards a gene expression biomarker set for human biological age",

abstract = "We have previously described a statistical model capable of distinguishing young (age -2, 3.5 3 10-4, 1.8 3 10-2, 1.5 3 10-2, respectively). We conclude that our expression signature of age is robust across three populations and may have utility for estimation of biological age.",

keywords = "Biological aging, Cell senescence, Mrna expression, Predictive model.",

author = "Holly, {Alice C.} and David Melzer and Pilling, {Luke C.} and William Henley and Hernandez, {Dena G.} and Singleton, {Andrew B.} and Stefania Bandinelli and Guralnik, {Jack M.} and Luigi Ferrucci and Harries, {Lorna W.}",

year = "2013",

doi = "10.1111/acel.12044",

language = "English (US)",

volume = "12",

pages = "324--326",

journal = "Aging Cell",

issn = "1474-9718",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Towards a gene expression biomarker set for human biological age

AU - Holly, Alice C.

AU - Melzer, David

AU - Pilling, Luke C.

AU - Henley, William

AU - Hernandez, Dena G.

AU - Singleton, Andrew B.

AU - Bandinelli, Stefania

AU - Guralnik, Jack M.

AU - Ferrucci, Luigi

AU - Harries, Lorna W.

PY - 2013

Y1 - 2013

N2 - We have previously described a statistical model capable of distinguishing young (age -2, 3.5 3 10-4, 1.8 3 10-2, 1.5 3 10-2, respectively). We conclude that our expression signature of age is robust across three populations and may have utility for estimation of biological age.

AB - We have previously described a statistical model capable of distinguishing young (age -2, 3.5 3 10-4, 1.8 3 10-2, 1.5 3 10-2, respectively). We conclude that our expression signature of age is robust across three populations and may have utility for estimation of biological age.

KW - Biological aging

KW - Cell senescence

KW - Mrna expression

KW - Predictive model.

UR - http://www.scopus.com/inward/record.url?scp=84878899881&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878899881&partnerID=8YFLogxK

U2 - 10.1111/acel.12044

DO - 10.1111/acel.12044

M3 - Article

C2 - 23311345

AN - SCOPUS:84878899881

SN - 1474-9718

VL - 12

SP - 324

EP - 326

JO - Aging Cell

JF - Aging Cell

IS - 2

ER -

Towards a gene expression biomarker set for human biological age

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this