Towards a blood-based diagnostic panel for bipolar disorder

Frieder Haenisch, Jason D. Cooper, Andreas Reif, Sarah Kittel-Schneider, Johann Steiner, F. Markus Leweke, Matthias Rothermundt, Nico J M van Beveren, Benedicto Crespo-Facorro, David W. Niebuhr, David N. Cowan, Natalya S. Weber, Robert H Yolken, Brenda W J H Penninx, Sabine Bahn

Research output: Contribution to journalArticle

Abstract

Background: Bipolar disorder (BD) is a costly, devastating and life shortening mental disorder that is often misdiagnosed, especially on initial presentation. Misdiagnosis frequently results in ineffective treatment. We investigated the utility of a biomarker panel as a diagnostic test for BD. Methods and findings: We performed a meta-analysis of eight case-control studies to define a diagnostic biomarker panel for BD. After validating the panel on established BD patients, we applied it to undiagnosed BD patients. We analysed 249 BD, 122 pre-diagnostic BD, 75 pre-diagnostic schizophrenia and 90 first onset major depression disorder (MDD) patients and 371 controls. The biomarker panel was identified using ten-fold cross-validation with lasso regression applied to the 87 analytes available across the meta-analysis studies.We identified 20 protein analytes with excellent predictive performance [area under the curve (AUC). ≥. 0.90]. Importantly, the panel had a good predictive performance (AUC 0.84) to differentiate 12 misdiagnosed BD patients from 90 first onset MDD patients, and a fair to good predictive performance (AUC 0.79) to differentiate between 110 pre-diagnostic BD patients and 184 controls. We also demonstrated the disease specificity of the panel. Conclusions: An early and accurate diagnosis has the potential to delay or even prevent the onset of BD. This study demonstrates the potential utility of a biomarker panel as a diagnostic test for BD.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalBrain, Behavior, and Immunity
Volume52
DOIs
StatePublished - Feb 1 2016

Fingerprint

Bipolar Disorder
Biomarkers
Diagnostic Errors
Area Under Curve
Routine Diagnostic Tests
Meta-Analysis
Depression
Mental Disorders
Case-Control Studies
Early Diagnosis
Schizophrenia

Keywords

  • Biomarker
  • Bipolar disorder
  • Diagnostic test
  • Differential diagnosis
  • Multiplex immunoassay

ASJC Scopus subject areas

  • Immunology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Haenisch, F., Cooper, J. D., Reif, A., Kittel-Schneider, S., Steiner, J., Leweke, F. M., ... Bahn, S. (2016). Towards a blood-based diagnostic panel for bipolar disorder. Brain, Behavior, and Immunity, 52, 49-57. https://doi.org/10.1016/j.bbi.2015.10.001

Towards a blood-based diagnostic panel for bipolar disorder. / Haenisch, Frieder; Cooper, Jason D.; Reif, Andreas; Kittel-Schneider, Sarah; Steiner, Johann; Leweke, F. Markus; Rothermundt, Matthias; van Beveren, Nico J M; Crespo-Facorro, Benedicto; Niebuhr, David W.; Cowan, David N.; Weber, Natalya S.; Yolken, Robert H; Penninx, Brenda W J H; Bahn, Sabine.

In: Brain, Behavior, and Immunity, Vol. 52, 01.02.2016, p. 49-57.

Research output: Contribution to journalArticle

Haenisch, F, Cooper, JD, Reif, A, Kittel-Schneider, S, Steiner, J, Leweke, FM, Rothermundt, M, van Beveren, NJM, Crespo-Facorro, B, Niebuhr, DW, Cowan, DN, Weber, NS, Yolken, RH, Penninx, BWJH & Bahn, S 2016, 'Towards a blood-based diagnostic panel for bipolar disorder', Brain, Behavior, and Immunity, vol. 52, pp. 49-57. https://doi.org/10.1016/j.bbi.2015.10.001
Haenisch F, Cooper JD, Reif A, Kittel-Schneider S, Steiner J, Leweke FM et al. Towards a blood-based diagnostic panel for bipolar disorder. Brain, Behavior, and Immunity. 2016 Feb 1;52:49-57. https://doi.org/10.1016/j.bbi.2015.10.001
Haenisch, Frieder ; Cooper, Jason D. ; Reif, Andreas ; Kittel-Schneider, Sarah ; Steiner, Johann ; Leweke, F. Markus ; Rothermundt, Matthias ; van Beveren, Nico J M ; Crespo-Facorro, Benedicto ; Niebuhr, David W. ; Cowan, David N. ; Weber, Natalya S. ; Yolken, Robert H ; Penninx, Brenda W J H ; Bahn, Sabine. / Towards a blood-based diagnostic panel for bipolar disorder. In: Brain, Behavior, and Immunity. 2016 ; Vol. 52. pp. 49-57.
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AU - Rothermundt, Matthias

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