Towards a better understanding of QT interval variability

Larisa G. Tereshchenko; Ronald D. Berger

doi:10.1177/2042098611421209

Towards a better understanding of QT interval variability

Larisa G. Tereshchenko, Ronald D. Berger

School of Medicine

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Guideline E14 recommends ‘Thorough QT Study’ as a standard assessment of drug-induced QT interval prolongation. At the same time, the value of drug-induced QTc prolongation as a surrogate marker for risk of life-threatening polymorphic ventricular tachycardia known as torsades des pointes remains controversial. Beat-to-beat variability of QT interval was recently proposed as an alternative metric. The following review addresses mechanisms of beat-to-beat QT variability, methods of QT interval variability measurements, and its prognostic value in clinical studies.

Original language	English (US)
Pages (from-to)	245-251
Number of pages	7
Journal	Therapeutic Advances in Drug Safety
Volume	2
Issue number	6
DOIs	https://doi.org/10.1177/2042098611421209
State	Published - Dec 2011

Keywords

QT interval
QT variability
drug safety
ventricular tachyarrhythmias

ASJC Scopus subject areas

Pharmacology (medical)

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10.1177/2042098611421209

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AU - Berger, Ronald D.

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AB - The International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Guideline E14 recommends ‘Thorough QT Study’ as a standard assessment of drug-induced QT interval prolongation. At the same time, the value of drug-induced QTc prolongation as a surrogate marker for risk of life-threatening polymorphic ventricular tachycardia known as torsades des pointes remains controversial. Beat-to-beat variability of QT interval was recently proposed as an alternative metric. The following review addresses mechanisms of beat-to-beat QT variability, methods of QT interval variability measurements, and its prognostic value in clinical studies.

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KW - QT variability

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KW - ventricular tachyarrhythmias

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Towards a better understanding of QT interval variability

Abstract

Keywords

ASJC Scopus subject areas

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