Toward Synergies of Ketamine and Psychotherapy

David S. Mathai, Victoria Mora, Albert Garcia-Romeu

Research output: Contribution to journalArticlepeer-review


Ketamine is a dissociative drug that has been used medically since the 1970s primarily as an anesthetic agent but also for various psychiatric applications. Anecdotal reports and clinical research suggest substantial potential for ketamine as a treatment in conjunction with psychological interventions. Here, we review historical and modern approaches to the use of ketamine with psychotherapy, discuss the clinical relevance of ketamine’s acute psychoactive effects, propose a unique model for using esketamine (one isomeric form of ketamine) with Acceptance and Commitment Therapy (ACT), and suggest considerations for moving medication-assisted psychotherapy forward as a field.

Original languageEnglish (US)
Article number868103
JournalFrontiers in Psychology
StatePublished - Mar 25 2022


  • ACT
  • dissociation
  • esketamine
  • ketamine
  • psychedelic
  • psychotherapy
  • therapy

ASJC Scopus subject areas

  • Psychology(all)


Dive into the research topics of 'Toward Synergies of Ketamine and Psychotherapy'. Together they form a unique fingerprint.

Cite this