Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.

Mark S. Silverberg, Jack Satsangi, Tariq Ahmad, Ian D R Arnott, Charles N. Bernstein, Steven R. Brant, Renzo Caprilli, Jean Frédéric Colombel, Christoph Gasche, Karel Geboes, Derek P. Jewell, Amir Karban, Edward V. Loftus, A. Salvador Peña, Robert H. Riddell, David B. Sachar, Stefan Schreiber, A. Hillary Steinhart, Stephan R. Targan, Severine VermeireB. F. Warren

Research output: Contribution to journalArticle

Abstract

The discovery of a series of genetic and serological markers associated with disease susceptibility and phenotype in inflammatory bowel disease has led to the prospect of an integrated classification system involving clinical, serological and genetic parameters. The Working Party has reviewed current clinical classification systems in Crohn's disease, ulcerative colitis and indeterminate colitis, and provided recommendations for clinical classification in practice. Progress with respect to integrating serological and genetic markers has been examined in detail, and the implications are discussed. While an integrated system is not proposed for clinical use at present, the introduction of a widely acceptable clinical subclassification is strongly advocated, which would allow detailed correlations among serotype, genotype and clinical phenotype to be examined and confirmed in independent cohorts of patients and, thereby, provide a vital foundation for future work.

Original languageEnglish (US)
JournalCanadian Journal of Gastroenterology
Volume19 Suppl A
StatePublished - Sep 2005
Externally publishedYes

Fingerprint

Gastroenterology
Inflammatory Bowel Diseases
Genetic Markers
Phenotype
Disease Susceptibility
Colitis
Ulcerative Colitis
Crohn Disease
Genotype

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease : report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. / Silverberg, Mark S.; Satsangi, Jack; Ahmad, Tariq; Arnott, Ian D R; Bernstein, Charles N.; Brant, Steven R.; Caprilli, Renzo; Colombel, Jean Frédéric; Gasche, Christoph; Geboes, Karel; Jewell, Derek P.; Karban, Amir; Loftus, Edward V.; Peña, A. Salvador; Riddell, Robert H.; Sachar, David B.; Schreiber, Stefan; Steinhart, A. Hillary; Targan, Stephan R.; Vermeire, Severine; Warren, B. F.

In: Canadian Journal of Gastroenterology, Vol. 19 Suppl A, 09.2005.

Research output: Contribution to journalArticle

Silverberg, MS, Satsangi, J, Ahmad, T, Arnott, IDR, Bernstein, CN, Brant, SR, Caprilli, R, Colombel, JF, Gasche, C, Geboes, K, Jewell, DP, Karban, A, Loftus, EV, Peña, AS, Riddell, RH, Sachar, DB, Schreiber, S, Steinhart, AH, Targan, SR, Vermeire, S & Warren, BF 2005, 'Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.', Canadian Journal of Gastroenterology, vol. 19 Suppl A.
Silverberg, Mark S. ; Satsangi, Jack ; Ahmad, Tariq ; Arnott, Ian D R ; Bernstein, Charles N. ; Brant, Steven R. ; Caprilli, Renzo ; Colombel, Jean Frédéric ; Gasche, Christoph ; Geboes, Karel ; Jewell, Derek P. ; Karban, Amir ; Loftus, Edward V. ; Peña, A. Salvador ; Riddell, Robert H. ; Sachar, David B. ; Schreiber, Stefan ; Steinhart, A. Hillary ; Targan, Stephan R. ; Vermeire, Severine ; Warren, B. F. / Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease : report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. In: Canadian Journal of Gastroenterology. 2005 ; Vol. 19 Suppl A.
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