Tourette syndrome

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tourette syndrome (TS) is a common, inherited neuropsychiatric disorder, characterized by the presence of chronic involuntary motor and vocal tics that wax and wane. In addition to tics, individuals with this syndrome often have a variety of concomitant psychopathologies, including obsessive-compulsive disorder, attention deficit hyperactivity disorder (ADHD), learning difficulties, and sleep abnormalities. TS is an inherited disorder, but the genetic abnormality and precise mode of transmission remain undetermined. Understanding of a role for nongenetic environmental influences is also evolving. The precise neuroanatomical localization remains unknown, but data suggest involvement of cortico-striatothalamo- cortical (CSTC) circuits. At a cellular level, the distribution of classical neurotransmitters within CSTC circuits raises the possibility that a variety of transmitters could be involved in the pathobiology of TS. Although abnormalities occur within dopaminergic systems, the precise cellular mechanism is not yet identified. An immune-mediated mechanism remains an unproven hypothesis. Active research continues, and the availability of animal models would be of major benefit.

Original languageEnglish (US)
Title of host publicationMovement Disorders
PublisherElsevier Inc.
Pages431-440
Number of pages10
ISBN (Print)9780120883820
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Singer, H. S., Smith-Hicks, C., & Lieberman, D. (2005). Tourette syndrome. In Movement Disorders (pp. 431-440). Elsevier Inc.. https://doi.org/10.1016/B978-012088382-0/50039-6