@article{798a4b4bca7640c780f46caa87484714,
title = "Total Synthesis of the Natural Product (+)-trans-Dihydronarciclasine via an Asymmetric Organocatalytic [3+3]-Cycloaddition and discovery of its potent anti-Zika Virus (ZIKV) Activity",
abstract = "An asymmetric total synthesis of the natural product (+)-trans-dihydronarciclasine has been achieved from α-azidoacetone and cinnamaldehyde precursors via a stepwise asymmetric [3+3]-organocatalytic cascade. The anti-Zika virus activity of this compound is also reported for the first time.",
keywords = "Zika, alkaloids, aminocyclitols, antiviral, asymmetric synthesis, organocatalysis, total synthesis",
author = "Omkar Revu and Carlos Zepeda-Vel{\'a}zquez and Nielsen, {Alex J.} and James McNulty and Yolken, {Robert H.} and Lorraine Jones-Brando",
note = "Funding Information: We thank the Stanley Medical Research Institute, NSERC (AJN) and CONACyT (CZ⨯V) for financial support of this work. OR and CZ⨯V contributed equally to this work. Publisher Copyright: {\textcopyright} 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2016",
month = nov,
day = "1",
doi = "10.1002/slct.201601536",
language = "English (US)",
volume = "1",
pages = "5895--5899",
journal = "ChemistrySelect",
issn = "2365-6549",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "18",
}