Total synthesis of the cyanobacterial metabolite nostodione A: Discovery of its antiparasitic activity against toxoplasma gondii

J. McNulty; K. Keskar; C. Bordón; R. Yolken; L. Jones-Brando

doi:10.1039/c4cc03904a

Total synthesis of the cyanobacterial metabolite nostodione A: Discovery of its antiparasitic activity against toxoplasma gondii

J. McNulty, K. Keskar, C. Bordón, R. Yolken, L. Jones-Brando

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route. A small assemblage of structural analogues were prepared and their cytotoxicity and anti-invasion activity against the protozoal parasite Toxoplasma gondii is reported for the first time.

Original language	English (US)
Pages (from-to)	8904-8907
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	64
DOIs	https://doi.org/10.1039/c4cc03904a
State	Published - Jul 15 2014

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c4cc03904a

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abstract = "A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route. A small assemblage of structural analogues were prepared and their cytotoxicity and anti-invasion activity against the protozoal parasite Toxoplasma gondii is reported for the first time.",

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AU - Yolken, R.

AU - Jones-Brando, L.

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Total synthesis of the cyanobacterial metabolite nostodione A: Discovery of its antiparasitic activity against toxoplasma gondii

Abstract

ASJC Scopus subject areas

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