Total synthesis of the cyanobacterial metabolite nostodione A: Discovery of its antiparasitic activity against Toxoplasma gondii

J. McNulty, K. Keskar, C. Bordón, Robert H Yolken, Lorraine V Brando

Research output: Contribution to journalArticle

Abstract

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route. A small assemblage of structural analogues were prepared and their cytotoxicity and anti-invasion activity against the protozoal parasite Toxoplasma gondii is reported for the first time. This journal is

Original languageEnglish (US)
Pages (from-to)8904-8907
Number of pages4
JournalChemical Communications
Volume50
Issue number64
DOIs
StatePublished - Aug 18 2014

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Antiparasitic Agents
Toxoplasma
Cytotoxicity
Metabolites
Biological Products
Parasites
nostodione A

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys
  • Medicine(all)

Cite this

Total synthesis of the cyanobacterial metabolite nostodione A : Discovery of its antiparasitic activity against Toxoplasma gondii. / McNulty, J.; Keskar, K.; Bordón, C.; Yolken, Robert H; Brando, Lorraine V.

In: Chemical Communications, Vol. 50, No. 64, 18.08.2014, p. 8904-8907.

Research output: Contribution to journalArticle

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