Total synthesis of the cyanobacterial metabolite nostodione A: Discovery of its antiparasitic activity against Toxoplasma gondii

J. McNulty, K. Keskar, C. Bordón, R. Yolken, L. Jones-Brando

Research output: Contribution to journalArticlepeer-review

Abstract

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route. A small assemblage of structural analogues were prepared and their cytotoxicity and anti-invasion activity against the protozoal parasite Toxoplasma gondii is reported for the first time. This journal is

Original languageEnglish (US)
Pages (from-to)8904-8907
Number of pages4
JournalChemical Communications
Volume50
Issue number64
DOIs
StatePublished - Aug 18 2014

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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