Abstract
Separation of genomic and nongenomic vitamin D activities was achieved by structural modification of 1,25-dihydroxy vitamin D3 by introduction of 16 and 23E double bonds. The modified compound 3, lacking a 1α-hydroxy group, exhibits only nongenomic activity. Its 1α-hydroxy relative 4 expresses fully both genomic and nongenomic activities. A total synthesis of analogues 3 and 4 is described. Copyright (C) 1997 Elsevier Science Ltd.
Original language | English (US) |
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Pages (from-to) | 2051-2059 |
Number of pages | 9 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 6 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1998 |
Externally published | Yes |
Keywords
- Calcium channel
- Genomic effect
- Nongenomic effect
- Transcriptional effect
- Vitamin D analogues
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry