Abstract
The antifungal, naturally occurring acetylenic fatty acid 6-nonadecynoic acid was synthesized in three steps (18% overall yield), for the first time starting with commercially available 1-tetradecyne. The synthesis developed herein will facilitate the further study of the antifungal properties of this naturally occurring acetylenic fatty acid. The 6-nonadecynoic acid exhibited the best antifungal activity (<4.3 μM) against Cryptococcus neoformans ATCC 66031 in Sabouraud Dextrose Broth (SDB) media. In our hands, it was not active against Candida albicans ATCC 14053 and Candida albicans ATCC 60193.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 441-443 |
| Number of pages | 3 |
| Journal | Archiv der Pharmazie |
| Volume | 338 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2005 |
| Externally published | Yes |
Keywords
- Acetylenic acids
- Antifungal
- C. neoformans
- Fatty acids
- Synthesis
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- General Chemistry
- Pharmacology